Sarcophagine (Sar) is a bicyclic cage-like metal

chelator Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These ligands are ...

molecule. derived from

cyclam Cyclam (1,4,8,11-tetraazacyclotetradecane) is an organic compound with the formula (NHCH2CH2NHCH2CH2CH2)2. Classified as an aza-crown ether, it is a white solid that is soluble in water. As a macrocyclic ligand, it binds strongly to many transitio ...

. Chemical formula of sarcophagine is 3,6,10,13,16,19-hexaazabicyclo(6,6,6)icosane and additional functional groups are often linked to this structure, such as in DiAmSar (1,8-diamino-Sar). This and many related

hexadentate A hexadentate ligand in coordination chemistry is a ligand that combines with a central metal atom with six bonds. One example of a hexadentate ligand that can form complexes with soft metal ions is TPEN. A commercially important hexadentate liga ...

clathrochelate In coordination chemistry, clathrochelates are ligands that encapsulate metal ions. Chelating ligands bind to metals more strongly than related monodentate ligands, and macrocyclic ligands bind more strongly than typical chelating ligands. It ...

s are prepared by

template reaction In coordination chemistry, a template reaction is any of a class of ligand-based reactions that occur between two or more adjacent coordination sites on a metal center. In the absence of the metal ion, the same organic reactants produce different ...

s. :

Sarcophagine

derivatives The derivative of a function is the rate of change of the function's output relative to its input value. Derivative may also refer to: In mathematics and economics * Brzozowski derivative in the theory of formal languages * Formal derivative, an ...

are used, for example, as ligands in

radiopharmaceuticals Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which is ...

that require incorporating a radioactive metal cation into an organic and/or biological structure, such as an antibody.

References

{{reflist Chelating agents Polyamines Secondary amines Hexadentate ligands