Ismaa Sadaf Farooqi is a

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...

Senior

Research fellow A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a p ...

Clinical Science Clinical research is a branch of medical research that involves people and aims to determine the effectiveness (efficacy) and safety of medications, devices, diagnostic products, and treatment regimens intended for improving human health. The ...

, professor of

Metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

and Medicine at the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

and a

consultant physician In the United Kingdom, Ireland, and parts of the Commonwealth, consultant is the title of a senior hospital-based physician or surgeon who has completed all of their specialist training and been placed on the specialist register in their chosen ...

Addenbrooke's Hospital Addenbrooke's Hospital is a large teaching hospital and research centre in Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county to ...

Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...

, UK.

Education

Farooqi was educated at the

University of Birmingham The University of Birmingham (informally Birmingham University) is a Public university, public research university in Birmingham, England. It received its royal charter in 1900 as a successor to Queen's College, Birmingham (founded in 1825 as ...

where she studied medicine, and was awarded a

Bachelor of Medicine, Bachelor of Surgery A Bachelor of Medicine, Bachelor of Surgery (; MBBS, also abbreviated as BM BS, MB ChB, MB BCh, or MB BChir) is a medical degree granted by medical schools or universities in countries that adhere to the United Kingdom's higher education trad ...

degree in 1993.Sadaf Farooqi's After working as a

pre-registration house officer Pre-registration house officer (PRHO), commonly referred to as house officer and less commonly as houseman, is a former official term for a grade of junior doctor that was, until 2005, the only job open to medical graduates in the United Kingdom ...

and

senior house officer A senior house officer (SHO) is a non-consultant hospital doctor in Ireland and many Commonwealth countries. SHOs usually have a minimum of 1 year post medical school training. SHOs are supervised in their work by consultants and registrars. In tr ...

, she moved into research and was awarded a PhD in 2001 from the

for research on the

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

of severe

childhood obesity Childhood obesity is a condition where excess adipose tissue, body fat negatively affects a child's health or well-being. As methods to determine body fat directly are difficult, the diagnosis of obesity is often based on Body mass index, BMI. ...

Research

Farooqi's research investigates the

genetics of obesity Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only i ...

. Using

candidate gene The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and Phenotype (clinical medicine), phenotypes or disease states. This is in contrast to ...

s found in patients with severe

obesity Obesity is a medical condition, considered by multiple organizations to be a disease, in which excess Adipose tissue, body fat has accumulated to such an extent that it can potentially have negative effects on health. People are classifi ...

, her research group have identified patients with

mutation In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, ...

s in

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

s encoding

leptin Leptin (from Ancient Greek, Greek λεπτός ''leptos'', "thin" or "light" or "small"), also known as obese protein, is a protein hormone predominantly made by adipocytes (cells of adipose tissue). Its primary role is likely to regulate long ...

, the

leptin receptor Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the ''LEPR'' gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD2 ...

and

biological target A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function. Examples of common classes of biological targets ...

s of leptin action, such as the

Melanocortin 4 receptor The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in regulating energy homeostasis, appetite, and sexual function. It plays a key role in metabolic processes and is predisposes to certain forms of obesity in humans. MC4R ...

(MC4R). Her group have also demonstrated that the central

melanocortin The melanocortins are a family of neuropeptide hormones which are the ligands of the melanocortin receptors.Ericson, M.D., et al., ''Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.'' Biochim Biophys Acta Mol B ...

axis plays a critical role in the regulation of human food intake. Research in her laboratory has shown that people who carry variants of the MC4R gene have an increased preference for high fat food (such as certain recipes of chicken korma), but a decreased preference for sugary foods like

Eton mess Eton mess is a traditional English dessert consisting of a mixture of strawberries or other berries, meringue, and whipped cream. First mentioned in print in 1893, it is commonly believed to originate from Eton College and is served at the annu ...

. Her research has also proven that mutations in the

KSR2 KSR2 is a gene which encodes Kinase Suppressor of Ras 2 in humans. The encoded protein plays a role in energy homeostasis, including fatty acid oxidation, glucose metabolism and basal metabolic rate (BMR). As a result, subsequent mutations in ...

gene are associated with

insulin resistance Insulin resistance (IR) is a pathological response in which cells in insulin-sensitive tissues in the body fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia. Insulin is a horm ...

and that genetic variation in the fat mass and obesity-associated protein (FTO) is associated with diminished hunger. Her research has been funded by the

Wellcome Collection Wellcome Collection is a museum and library based at 183 Euston Road, London, England, displaying a mixture of medical artefacts and original artworks exploring "ideas about the connections between medicine, life and art". Founded in 2007, the W ...

Addenbrooke's Charitable Trust Addenbrooke's Charitable Trust (ACT; established 2005) is a charity based at Addenbrooke's Hospital Addenbrooke's Hospital is a large teaching hospital and research centre in Cambridge Cambridge ( ) is a List of cities in the United King ...

and the

Framework Programmes for Research and Technological Development The Framework Programmes for Research and Technological Development, also called Framework Programmes or abbreviated FP1 to FP9, are funding programmes created by the European Union/European Commission to support and foster research in the Europe ...

(FP7) from the

European Union The European Union (EU) is a supranational union, supranational political union, political and economic union of Member state of the European Union, member states that are Geography of the European Union, located primarily in Europe. The u ...

Awards and honours

Farooqi was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

in 2021. Farooqi was elected a

Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of the ...

(FMedSci) in 2013. Her citation on election reads: Farooqi was interviewed by

Jim Al-Khalili Jameel Sadik "Jim" Al-Khalili (; born 20 September 1962) is an Iraqi-British theoretical physicist and science populariser. He is professor of theoretical physics and chair in the public engagement in science at the University of Surrey. He is a ...

on ''

The Life Scientific ''The Life Scientific'' is a BBC Radio 4 science programme, presented by Jim Al-Khalili, in which each episode is dedicated to the biography and work of a living scientist. The programme consists of an interview between Al-Khalili and the featur ...

'', first broadcast on

BBC Radio 4 BBC Radio 4 is a British national radio station owned and operated by the BBC. The station replaced the BBC Home Service on 30 September 1967 and broadcasts a wide variety of spoken-word programmes from the BBC's headquarters at Broadcasti ...

in 2017. Farooqi was awarded the American Diabetes Association's Outstanding Scientific Achievement Award in 2019.

References

{{DEFAULTSORT:Farooqi, Sadaf Living people Wellcome Trust Alumni of the University of Cambridge Fellows of the Academy of Medical Sciences (United Kingdom) Academics of the University of Cambridge 20th-century British medical doctors 21st-century British medical doctors Year of birth missing (living people) British women medical doctors British women scientists Fellows of the Royal Society