A major north–south highway extending almost the entire length of the

Florida Florida ( ; ) is a U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders the Gulf of Mexico to the west, Alabama to the northwest, Georgia (U.S. state), Georgia to the north, the Atlantic ...

peninsula A peninsula is a landform that extends from a mainland and is only connected to land on one side. Peninsulas exist on each continent. The largest peninsula in the world is the Arabian Peninsula. Etymology The word ''peninsula'' derives , . T ...

, State Road 45 (SR 45) is the unsigned

Florida Department of Transportation The Florida Department of Transportation (FDOT) is a decentralized agency charged with the establishment, maintenance, and regulation of public transportation in the U.S. state of Florida. The department was formed in 1969. It absorbed the power ...

designation of most of the current

U.S. Route 41 U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miam ...

in Florida. The southern terminus of SR 45 is an intersection with SR 90 in downtown

Naples Naples ( ; ; ) is the Regions of Italy, regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 908,082 within the city's administrative limits as of 2025, while its Metropolitan City of N ...

; the northern terminus is an intersection with

US 441 U.S. Route 441 (US 441) is a auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top, Tennessee. Between its termini, US 441 travels through the states of Florida, Georgia, North ...

( SR 25) in

High Springs High Springs is a city in Alachua County, Florida, United States. It is the fourth-largest city in Alachua County and seventh-largest in North Central Florida. The population was 6,215 at the 2020 census, up from 5,350 at the 2010 census. It is ...

. South of Causeway Boulevard ( SR 676) near

Tampa Tampa ( ) is a city on the Gulf Coast of the United States, Gulf Coast of the U.S. state of Florida. Tampa's borders include the north shore of Tampa Bay and the east shore of Old Tampa Bay. Tampa is the largest city in the Tampa Bay area and t ...

, SR 45 is also known as the

Tamiami Trail The Tamiami Trail () is the southernmost of U.S. Highway 41 (US 41) from State Road 60 (SR 60) in Tampa to US 1 in Miami. A portion of the road also has the hidden designation of State Road 90 (SR 90). The north� ...

. South and east of Naples, US 41 turns eastward as SR 90 as the Tamiami Trail crosses the

Everglades The Everglades is a natural region of flooded grasslands in the southern portion of the U.S. state of Florida, comprising the southern half of a large drainage basin within the Neotropical realm. The system begins near Orlando with the K ...

on its way to

Miami Miami is a East Coast of the United States, coastal city in the U.S. state of Florida and the county seat of Miami-Dade County, Florida, Miami-Dade County in South Florida. It is the core of the Miami metropolitan area, which, with a populat ...

; north of High Springs, US 41 overlaps US 441 (SR 25) until their split in

Lake City Lake City may refer to: Places *Lake City, Arkansas * Lake City, California (disambiguation) *Lake City, Modoc County, California * Lake City, Nevada County, California *Lake City, Colorado *Lake City, Florida * Lake City, Georgia * Lake City, I ...

(from there US 41 continues to the

Georgia Georgia most commonly refers to: * Georgia (country), a country in the South Caucasus * Georgia (U.S. state), a state in the southeastern United States Georgia may also refer to: People and fictional characters * Georgia (name), a list of pe ...

border with the hidden SR 25 designation).

Separations of US 41 and SR 45 between SR 45 termini

SR 45 away from US 41

* Business US 41 -

Venice Venice ( ; ; , formerly ) is a city in northeastern Italy and the capital of the Veneto Regions of Italy, region. It is built on a group of 118 islands that are separated by expanses of open water and by canals; portions of the city are li ...

* Business US 41 -

Bradenton Bradenton ( ) is a city in and the county seat of Manatee County, Florida, United States. As of the 2020 census, the city's population is 55,698, up from 49,546 at the 2010 census. It is a principal city in the Sarasota metropolitan area. Dow ...

Memphis Memphis most commonly refers to: * Memphis, Egypt, a former capital of ancient Egypt * Memphis, Tennessee, a major American city Memphis may also refer to: Places United States * Memphis, Alabama * Memphis, Florida * Memphis, Indiana * Mem ...

* Business US 41 (historic US 541) - Rockport to

Ybor City Ybor City ( ) is a historic neighborhood just northeast of downtown Tampa, downtown Tampa, Florida, United States. It was founded in the 1880s by Vicente Martinez Ybor and other cigar manufacturers and populated by thousands of immigrants, mai ...

* SR 60 - Tampa to Ybor City *SR 45 (not overlapped between Adamo Drive/SR 60 and Hillsborough Avenue/US 41- 92- SR 600) - Tampa

US 41 away from SR 45

* SR 45A - Venice *

US 301 U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs from Biddles Corner, Delaware, at Delaware Route 1 to Sarasota, Florida, at U.S. Route 41. It passes through the states of Delaware, ...

- Bradenton, concurrent with SR 55 * SR 55 - Bradenton to Memphis * SR 599 - Rockport to Tampa *

US 92 U.S. Highway 92 (US 92) is a U.S. Route entirely in the state of Florida. The western terminus is at US 19 Alternate (US 19 Alt.) and State Road 687 (SR 687)) in downtown St. Petersburg. The eastern terminus is at SR A1A ...

(SR 600) - Tampa

Additional concurrencies with SR 45

*SR 45-55 - Memphis *

US 41 U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway System, United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part i ...

/SR 45- 60 - Ybor City *

/SR 45-

700 The denomination 700 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Byzantine Empire * Avar and Slavic tribes co ...

- Brooksville *

/ SR 44-45 -

Inverness Inverness (; ; from the , meaning "Mouth of the River Ness") is a city in the Scottish Highlands, having been granted city status in 2000. It is the administrative centre for The Highland Council and is regarded as the capital of the Highland ...

* Alt US 27-US 41/SR 45-

500 500 may refer to: * 500 (number) * 500 BC * AD 500 Buildings and places * 500 Boylston Street in Boston * 500 Brickell in Miami * 500 Capitol Mall in Sacramento * 500 Fifth Avenue * 500 Renaissance Center, one of seven buildings in the GM ...

- Williston *

US 27 U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I ...

-US 41/SR 45 - Williston to High Springs

Major intersections

State Road 45A

State Road 45A (SR 45A) is the Venice Bypass, a segment along U.S. Route 41 (US 41) east of the

, which was originally part of US 41 until 1965 when that segment was redesignated as US 41 Bus after the

Intracoastal Waterway The Intracoastal Waterway (ICW) is a Navigability, inland waterway along the Atlantic and Gulf of Mexico coasts of the United States, running from Massachusetts southward along the Atlantic Seaboard and around the southern tip of Florida, the ...

(ICW) was dredged through Venice by the

U.S. Army Corps of Engineers The United States Army Corps of Engineers (USACE) is the military engineering branch of the United States Army. A direct reporting unit (DRU), it has three primary mission areas: Engineer Regiment, military construction, and civil wor ...

in 1964. The route begins near Shamrock Boulevard in Venice Gardens and terminates at Venetia Bay Boulevard in the Eastgate section of Venice.

References

{{Reflist

External links

Florida Route Log (SR 45)
045 045 045 045 045 045 045 045 045 045 045 045 045 045 U.S. Route 41