NHP2-like protein 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''SNU13''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Originally named because of its sequence similarity to the ''
Saccharomyces cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungal microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have be ...
'' NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the
4/U6.U5tri-snRNP
snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre- ...
. It binds to the
5' stem-loop
Stem-loops are nucleic acid Biomolecular structure, secondary structural elements which form via intramolecular base pairing in single-stranded DNA or RNA. They are also referred to as hairpins or hairpin loops. A stem-loop occurs when two regi ...
of
U4 snRNA U4, U-4, or U04 may refer to:
Science and technology
* U4 spliceosomal RNA, a non-coding RNA component of the major U2-dependent spliceosome
* Haplogroup U4 (mtDNA), a human genetic group
* U4, unitary group of degree 4
* U-47700, a synthetic opio ...
. Two transcript variants encoding the same protein have been found for this gene.
Interactions
SNU13 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
RAD17
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the ''RAD17'' gene.
Function
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene ...
.
References
Further reading
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