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Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10, is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''SLC38A10''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Cellular localization

Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles. Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.


Cancer

A SLC38A family member has been observed progressively downregulated in
Human papillomavirus Human papillomavirus infection (HPV infection) is caused by a DNA virus from the ''Papillomaviridae'' family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. In some cases, an HPV infection persists and r ...
-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.


References


Further reading

* Solute carrier family Genes mutated in mice {{gene-17-stub