The Rubella virus 3′ cis-acting element

RNA Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...

family represents a ''cis''-acting element found at the 3′ UTR in the

rubella virus Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy. Rube ...

. This family contains three conserved step loop structures.

Calreticulin Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the ''CALR'' gene. Calreticulin is a multifunctional soluble prot ...

(CAL), which is known to bind calcium in most

eukaryotic The eukaryotes ( ) constitute the Domain (biology), domain of Eukaryota or Eukarya, organisms whose Cell (biology), cells have a membrane-bound cell nucleus, nucleus. All animals, plants, Fungus, fungi, seaweeds, and many unicellular organisms ...

cells, is able to specifically bind to the first

stem loop Stem-loops are nucleic acid secondary structural elements which form via intramolecular base pairing in single-stranded DNA or RNA. They are also referred to as hairpins or hairpin loops. A stem-loop occurs when two regions of the same nucleic ...

of this RNA. CAL binding is thought to be related to viral

pathogenesis In pathology, pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes . Descript ...

and in particular

arthritis Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of ...

which occurs frequently in rubella infections in adults and is independent of viral

viability Viability or viable may refer to: Biology, medicine or ecology * Viability selection, the selection of individual organisms who can survive until they are able to reproduce * Fetal viability, the ability of a fetus to survive outside of the uter ...

. All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal.

References

External links

* - Calreticulin protein family * Cis-regulatory RNA elements Rubella Togaviruses {{molecular-cell-biology-stub

See also

References

External links