Roeland "Roel" Nusse (born 9 June 1950,

Amsterdam Amsterdam ( , ; ; ) is the capital of the Netherlands, capital and Municipalities of the Netherlands, largest city of the Kingdom of the Netherlands. It has a population of 933,680 in June 2024 within the city proper, 1,457,018 in the City Re ...

) is a professor at

Stanford University Leland Stanford Junior University, commonly referred to as Stanford University, is a Private university, private research university in Stanford, California, United States. It was founded in 1885 by railroad magnate Leland Stanford (the eighth ...

and an investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

. His research was seminal in the discovery of

Wnt signaling In cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the ...

, a family of pleiotropic regulators involved in development and disease.

Research

Nusse received his BSc in biology and his

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

from the

University of Amsterdam The University of Amsterdam (abbreviated as UvA, ) is a public university, public research university located in Amsterdam, Netherlands. Established in 1632 by municipal authorities, it is the fourth-oldest academic institution in the Netherlan ...

. Nusse did a postdoctoral fellowship under the guidance of

Harold Varmus Harold Eliot Varmus (born December 18, 1939) is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center. He was ...

at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...

. In 1982, Nusse and Varmus discovered the Wnt1 gene. After his postdoctoral fellowship, Nusse joined the Netherlands Cancer Institute expanding on the earlier work on the Wnt pathway and identifying the pathway in fruit flies. In 1990, he joined the department of

Developmental Biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...

. His lab is currently focused on the role of Wnt in stem cell development and tissue repair.

Awards

Nusse received the

Peter Debye Peter Joseph William Debye ( ; born Petrus Josephus Wilhelmus Debije, ; March 24, 1884 – November 2, 1966) was a Dutch-American physicist and physical chemist, and Nobel laureate in Chemistry. Biography Early life Born in Maastricht, Neth ...

Prize from the

University of Maastricht A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Uni ...

in 2000. He is a member of the

U.S. National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

, and the

Royal Netherlands Academy of Arts and Sciences The Royal Netherlands Academy of Arts and Sciences (, KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed in the Trippenhuis in Amsterdam. In addition to various advisory a ...

(since 1997). He is a fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

. He won a

Breakthrough Prize The Breakthrough Prizes are a set of international awards bestowed in three categories by the Breakthrough Prize Board in recognition of scientific advances. The awards are part of several "Breakthrough" initiatives founded and funded by Yuri M ...

in 2017. In 2020 he received the

Canada Gairdner International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...

References

External links

Roeland Nusse Lab at Stanford University
{{DEFAULTSORT:Nusse, Roel 1950 births Living people Developmental biologists Dutch biologists Howard Hughes Medical Investigators Members of the Royal Netherlands Academy of Arts and Sciences Members of the United States National Academy of Sciences Dutch molecular biologists Scientists from Amsterdam Stanford University School of Medicine faculty University of Amsterdam alumni Academic staff of the University of Amsterdam University of California, San Francisco alumni