RnaG is a small regulatory
non-coding RNA encoded by the virulence plasmid of ''
Shigella flexneri
''Shigella flexneri'' is a species of Gram-negative bacteria in the genus '' Shigella'' that can cause diarrhea in humans. Several different serogroups of ''Shigella'' are described; ''S. flexneri'' belongs to group ''B''. ''S. flexneri'' infe ...
'', a Gram-negative pathogenic bacterium that causes human
bacillary dysentery. It is a first
regulatory RNA characterised in ''S. flexneri''. The
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
is 450
nucleotides long (which makes it one of the largest regulatory sRNAs) and it contains a region with specific secondary structure that interacts with ''icsA'' (
virG')
mRNA and forms a
transcription terminator. Acting as
antisense, RnaG is transcribed from the complementary strand of its target, ''icsA'' mRNA.
The activity of the incA protein is crucial for spreading of the bacterial pathogen in the host cells.
References
{{DEFAULTSORT:RnaG antisense RNA
Antisense RNA