Riligustilide is a
nonsteroidal A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.
List of nonsteroidal steroid receptor mo ...
phytoprogestogen that is found in ''
Ligusticum chuanxiong''.
It is a very weak
agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
of the
progesterone receptor
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
In humans, PR is encoded by a single ''PGR'' gene resi ...
(EC
50 ≈ 81 μM).
Another compound in the plant,
3,8-dihydrodiligustilide, is also a phytoprogestogen, but is almost 1,000-fold more
potent in comparison (
EC50 = 90 nM).
See also
*
Kaempferol
Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. It is also found in propolis extracts. Kaempferol i ...
*
Tanaproget
References
Progestogens
Cyclobutanes
Lactones
Alkene derivatives
Spiro compounds
Propyl compounds
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