TRNase Z (, ''3 tRNase'', ''tRNA 3 endonuclease'', ''RNase Z'', ''3' tRNase'') is an
enzyme that, among other things,
catalyses the reactions involved in the maturation of
tRNAs. Here, it endonucleolytically cleaves the
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
and removes extra 3'
nucleotides from the tRNA precursor, generating the 3' termini of
tRNAs. A 3'-
hydroxy group
In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydroxy ...
is left at the tRNA terminus and a 5'-
phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as
mascRNA.
The enzyme does not use a
cofactor.
References
External links
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EC 3.1.26