RhoGAP domain is an evolutionary conserved
protein domain
In molecular biology, a protein domain is a region of a protein's Peptide, polypeptide chain that is self-stabilizing and that Protein folding, folds independently from the rest. Each domain forms a compact folded Protein tertiary structure, thre ...
of
GTPase activating protein GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are a ...
s towards
Rho
Rho (; uppercase Ρ, lowercase ρ or ; or ) is the seventeenth letter of the Greek alphabet. In the system of Greek numerals it has a value of 100. It is derived from Phoenician alphabet, Phoenician letter resh . Its uppercase form uses the same ...
/
Rac
RAC or Rac may refer to:
Organizations
* Radio Amateurs of Canada
* RATCH-Australia Corporation, electricity generator
* Refugee Action Collective (Victoria), Melbourne, Australia
* Religious Action Center of Reform Judaism, US
* Rent-A-Cent ...
/
Cdc42
Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the ''CDC42'' gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in ''S. cerevisiae'' (yeast) as a mediator of ...
-like small
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...
s.
Human proteins containing this domain
ABR;
ARHGAP1
Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene.
Interactions
ARHGAP1 has been shown to interact with:
* BNIP2
* CDC42, and
* RHOA
Transforming protein RhoA, also known as Ras homolog famil ...
;
ARHGAP10;
ARHGAP11A;
ARHGAP11B
''ARHGAP11B'' is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ''ARHGAP1 ...
;
ARHGAP12
Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''ARHGAP1'' gene.
Interactions
ARHGAP1 has been shown to interact with:
* BNIP2
* CDC42, and
* RHOA
Transforming protein RhoA, also known as Ras homolog family ...
;
ARHGAP15;
ARHGAP17;
ARHGAP18
Rho GTPase activating protein 18 is a protein that in humans is encoded by the ''ARHGAP18'' gene. The gene is also known as ''MacGAP'' and ''bA307O14.2''. ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling ...
;
ARHGAP19;
ARHGAP20;
ARHGAP21;
ARHGAP22;
ARHGAP23;
ARHGAP24
Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ''ARHGAP24'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in ...
;
ARHGAP25;
ARHGAP26;
ARHGAP27;
ARHGAP28;
ARHGAP29;
ARHGAP30;
ARHGAP4
Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ''ARHGAP4'' gene. It has been shown to regulate cell motility
Motility is the ability of an organism to move independently using metabolism, metabolic energy. This b ...
;
ARHGAP5
Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ''ARHGAP5'' gene.
Function
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrol ...
;
ARHGAP6;
ARHGAP8;
ARHGAP9;
BCR;
BPGAP1;
C1;
C5orf5;
CDGAP;
CENTD1;
CENTD2;
CENTD3;
CHN1;
CHN2
Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the ''CHN2'' gene.
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/diacylglycerol-type zinc finger, a Rho-GAP domain and an SH2 domain ...
;
DEPDC1
DEP domain containing 1 is a protein in humans that is encoded by the DEPDC1 gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is tr ...
;
DEPDC1A;
DEPDC1B;
DLC1
Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the ''DLC1'' gene.
This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p ...
;
FAM13A1;
FKSG42; GMIP;
GRLF1;
HMHA1;
INPP5B
Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the ''INPP5B'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of ...
;
KIAA1688;
LOC553158;
MYO9A;
MYO9B;
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the ''OCRL'' gene located on the X chromosome in humans.
This gene encodes an inositol polyphosphate 5-phosphatase. The ...
;
OPHN1;
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the ''PIK3R1'' gene.
Function
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. ...
;
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the ''PIK3R2'' gene.
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.
Interactions
...
;
PRR5;
RACGAP1
Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''RACGAP1'' gene.
Function
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO ( ...
;
RACGAP1P;
RALBP1
RalA-binding protein 1 is a protein that in humans is encoded by the ''RALBP1'' gene.
Interactions
RALBP1 has been shown to Protein-protein interaction, interact with:
* Cyclin B1,
* HSF1,
* RALA,
* RALB, and
* REPS2.
References
Furt ...
;
RICH2;
RICS
The Royal Institution of Chartered Surveyors (RICS) is a global professional body for those working in the Built Environment, Construction, Land, Property and Real Estate. The RICS was founded in London in 1868. It works at a cross-governmental ...
;
SH3BP1;
SLIT1
Slit homolog 1 protein is a protein that in humans is encoded by the ''SLIT1'' gene.
References
Further reading
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{{protein-stub
Slit proteins ...
;
SNX26
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the ''SNX26'' gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide
Phosphati ...
;
SRGAP1;
SRGAP2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the ''SRGAP2'' gene. It is involved in neuronal migration and differentiation and plays a crit ...
;
SRGAP3
SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the ''SRGAP3'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleot ...
;
STARD13;
STARD8;
SYDE1;
SYDE2;
Notes
References
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Protein domains
Peripheral membrane proteins
{{membrane-protein-stub