Raymond Perry Ahlquist (July 26, 1914 – April 15, 1983) was an American

pharmacist A pharmacist, also known as a chemist in English in the Commonwealth of Nations, Commonwealth English, is a healthcare professional who is knowledgeable about preparation, mechanism of action, clinical usage and legislation of medications in ...

and

pharmacologist Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between ...

. He published seminal work in 1948 that divided

adrenoceptors The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like bet ...

into α- and β-adrenoceptor subtypes. This discovery explained the activity of several existing drugs and also laid the groundwork for new

drugs A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestio ...

including the widely prescribed

beta blockers Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms (arrhythmia), and to protect the heart from a second heart attack after a first heart attack (secondary prevention). ...

Early life and education

Ahlquist was born on July 26, 1914, in Missoula,

Montana Montana ( ) is a landlocked U.S. state, state in the Mountain states, Mountain West subregion of the Western United States. It is bordered by Idaho to the west, North Dakota to the east, South Dakota to the southeast, Wyoming to the south, an ...

. Both of his parents came from

Sweden Sweden, formally the Kingdom of Sweden, is a Nordic countries, Nordic country located on the Scandinavian Peninsula in Northern Europe. It borders Norway to the west and north, and Finland to the east. At , Sweden is the largest Nordic count ...

. His father was an auditor at the railway company

Northern Pacific Railway The Northern Pacific Railway was an important American transcontinental railroad that operated across the northern tier of the Western United States, from Minnesota to the Pacific Northwest between 1864 and 1970. It was approved and chartered b ...

. In 1940, Ahlquist graduated with a

Ph.D. A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

degree in

pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...

from the

University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...

Seattle Seattle ( ) is the most populous city in the U.S. state of Washington and in the Pacific Northwest region of North America. With a population of 780,995 in 2024, it is the 18th-most populous city in the United States. The city is the cou ...

, the first person to be awarded such a degree from that institution.

Career and research

Ahlquist spent four years as a faculty member at

South Dakota State University South Dakota State University (SDSU or SD State) is a public university, public Land-grant university, land-grant research university in Brookings, South Dakota, United States. Founded in 1881, it is the state's largest university and is the sec ...

in Brookings. In 1944 he became

assistant professor Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doct ...

at the

Medical College of Georgia The Medical College of Georgia (often referred to as MCG) is the medical school of Augusta University, the state's only public medical school, and one of the top 10 largest medical schools in the United States. Established in 1828 as the Medical ...

in Augusta. In 1946 he was appointed associate professor in the same institution and from 1948 to 1963 he was the chair of pharmacology. In 1963 he was appointed associate dean for basic sciences and research coordinator for the medical college. Between 1970 and 1977 he was again chair of pharmacology and in 1977 he was appointed Charbonnier Professor of Pharmacology, a post he held until his death.

Adrenoceptors

While working on a project in western South Dakota, Ahlquist searched for a substitute for the Chinese plant-derived and scarce

ephedrine Ephedrine is a central nervous system (CNS) stimulant and sympathomimetic agent that is often used to prevent hypotension, low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred ...

. It has similar activity to that of

adrenaline Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands a ...

and

noradrenaline Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. The name "noradrenaline" (from ...

- a sympathomimetic, i.e. a substance that stimulates the

sympathetic nervous system The sympathetic nervous system (SNS or SANS, sympathetic autonomic nervous system, to differentiate it from the somatic nervous system) is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous sy ...

. The actions of the sympathomimetics confused pharmacologists and physiologists at the time as they could not explain how a single agent could have both excitatory and inhibitory effects. In his famous work Ahlquist chose six agonists, including

epinephrine Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands a ...

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic compound, organic chemical in the catecholamine family that functions in the brain and human body, body as a hormone, neurotransmitter and neuromodulator. The ...

, α-methyl noradrenaline and

isoprenaline Isoprenaline, also known as isoproterenol and sold under the brand name Isuprel among others, is a sympathomimetic medication which is used in the treatment of acute bradycardia (slow heart rate), heart block, and rarely for asthma, among other ...

, and examined their effects on several organs, including

blood vessel Blood vessels are the tubular structures of a circulatory system that transport blood throughout many Animal, animals’ bodies. Blood vessels transport blood cells, nutrients, and oxygen to most of the Tissue (biology), tissues of a Body (bi ...

s and the

heart The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...

. He found that the six substances possessed different rank orders of

potency Potency may refer to: * Potency (pharmacology), a measure of the activity of a drug in a biological system * Virility * Cell potency, a measure of the differentiation potential of stem cells * In homeopathic dilutions, potency is a measure of ho ...

that differed depending on the tissue. For example, the rank order of potency was "adrenaline > noradrenaline > α-methyl noradrenaline > isoprenaline" in promoting contraction of blood vessels, but the rank order was "isoprenaline > adrenaline > α-methyl noradrenaline > norepinephrine" in the heart. Ahlquist concluded that there were two different receptors. The receptors with the first rank order (that is, for example, for blood vessel contraction), he called α-adrenoceptors (alpha adrenotropic receptor) receptors, while the second rank order (for instance, for the promotion of cardiac activity), he called β-adrenoceptors. Simultaneously both cautious and forward-looking, he wrote: "Although little can be said at the present time as to the fundamental nature of the adrenotropic receptor and the difference between the ''alpha'' and ''beta'' types, this concept should be useful when studying the various actions of epinephrine, the actions and interactions of the sympathomimetic agents, and the effects of sympathetic nerve stimulation." Ahlquist's classification was initially dismissed and took some time to be accepted, but it went on to have a major impact on

. The

manuscript A manuscript (abbreviated MS for singular and MSS for plural) was, traditionally, any document written by hand or typewritten, as opposed to mechanically printed or reproduced in some indirect or automated way. More recently, the term has ...

was first rejected by the ''

Journal of Pharmacology and Experimental Therapeutics A journal, from the Old French ''journal'' (meaning "daily"), may refer to: *Bullet journal, a method of personal organization *Diary, a record of personal secretive thoughts and as open book to personal therapy or used to feel connected to onesel ...

'', but was subsequently accepted for publication by the ''

American Journal of Physiology The ''American Journal of Physiology'' is a peer-reviewed scientific journal on physiology published by the American Physiological Society. Vols. for 1898–1941 and 1948-56 include the Society's proceedings, including abstracts of papers present ...

''. As for Ahlquist's inquiry into the nature of adrenoceptors, we now know that they are

G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related ...

s and humans possess a total of nine different adrenoceptors ( α1A, α1B, α1D, α2A, α2B α2C, β1, β2, β3). In the field of therapeutics, his discovery laid the foundation for the development of

beta blocker Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms ( arrhythmia), and to protect the heart from a second heart attack after a first heart attack ( secondary prevention ...

s by

Sir James Black Sir James Whyte Black (14 June 1924 – 22 March 2010) was a Scottish physician and pharmacologist. Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational ...

to treat heart disease and also reduce high

blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...

Other work

Ahlquist's other scientific work also included studies on the

of the sympathetic

nervous system In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. Th ...

. His research contributed to the discovery of

tolazoline Tolazoline is a non-selective Competitive antagonist, competitive Alpha blocker#Classification, α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been ...

, a non-selective α-adrenergic receptor antagonist with a completely different

chemical structure A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds. Its determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target m ...

from adrenaline and noradrenaline and in 1958,

dichloroisoprenaline Dichloroisoprenaline (DCI), also known as dichloroisoproterenol, was the first beta blocker ever to be developed. It is non-selective for the β1-adrenergic and β2-adrenergic receptors. DCI has low potency and acts as a partial agonist/antagoni ...

, the first beta-blocker. He also contributed to the discovery that

peristalsis Peristalsis ( , ) is a type of intestinal motility, characterized by symmetry in biology#Radial symmetry, radially symmetrical contraction and relaxation of muscles that propagate in a wave down a tube, in an wikt:anterograde, anterograde dir ...

is enhanced by α-adrenoceptors and inhibited by β-adrenoceptors. In his last published article in 1980, he looked back to the 1948 publication. The impact of the 1948 publication is evident by the number of times it has been cited (5,220 times as of 28-01-2025).

Awards

Ahlquist was awarded the Oscar B. Hunter Memorial Award in

Therapeutics A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx. As a rule, each therapy has indications an ...

, the Ciba Award for Hypertension Research and the

Albert Lasker Award In 1945 Albert Lasker and Mary Woodard Lasker created the Lasker Awards. Every year since then the award has been given to the living person considered to have made the greatest contribution to medical science or who has demonstrated public ser ...

for Clinical Medical Research.

Personal

Ahlquist met his wife Dorothy Duff Ahlquist in

Death

Ahlquist died on April 15, 1983, in Augusta,

Georgia Georgia most commonly refers to: * Georgia (country), a country in the South Caucasus * Georgia (U.S. state), a state in the southeastern United States Georgia may also refer to: People and fictional characters * Georgia (name), a list of pe ...

References

External links

Biography on southalabama.edu
{{DEFAULTSORT:Ahlquist, Raymond P. 1914 births 1983 deaths American people of Swedish descent Recipients of the Lasker–DeBakey Clinical Medical Research Award American pharmacologists 20th-century American chemists