RasGEF domain is domain found in the CDC25

family Family (from la, familia) is a group of people related either by consanguinity (by recognized birth) or affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its members and of society. Idea ...

guanine nucleotide exchange factor Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated struct ...

s for Ras-like small

GTPase GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...

s. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see ) and this CDC25 (RasGEF) family. The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.

Human proteins containing this domain

KNDC1;

PLCE1 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) is an enzyme that in humans is encoded by the ''PLCE1'' gene. This gene encodes a phospholipase enzyme (PLCE1) that catalyzes the hydrolysis of phosphatidylinositol-4,5-bi ...

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RALGDS Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the ''RALGDS'' gene in humans. Interactions RALGDS has been shown to interact with: * Arrestin beta 1, * Arrestin beta 2, * HRAS, * KRAS, * MRAS, * RAP1A, * ...

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RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 is a protein in humans that is encoded by the RALGPS1 gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meanin ...

; RALGPS2;

RAPGEF1 Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ''RAPGEF1'' gene. Function The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor-type S ...

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RAPGEF2 Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ''RAPGEF2'' gene. RAPGEF2 is a cyclic AMP binding protein. Function Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regul ...

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RAPGEF3 Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the ''RAPGEF3'' gene. As the n ...

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RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the ''RAPGEF4'' gene. Epac2 is a target of cAMP, a major second messenger in v ...

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RAPGEF5 Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ''RAPGEF5'' gene. Members of the Ras subfamily, RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches th ...

; RAPGEF6; RAPGEFL1; RASGEF1A; RASGEF1B; RASGEF1C; RASGRF1; RASGRF2;

RASGRP1 RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the ''RASGRP1'' gene. Function RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanin ...

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RASGRP2 RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the ''RASGRP2'' gene. The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand cal ...

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RASGRP3 Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the ''RASGRP3'' gene. Function Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle bet ...

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RASGRP4 RAS guanyl releasing protein 4 is a protein in humans that is encoded by the RASGRP4 gene in chromosome 19. The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exc ...

; RGL1;

RGL2 Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the ''RGL2'' gene. Interactions RGL2 has been shown to interact Advocates for Informed Choice, dba interACT or interACT Advocates for Inters ...

; RGL3; RGL4/RGR;

SOS1 Son of sevenless homolog 1 is a protein that in humans is encoded by the ''SOS1'' gene. Function SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with RAS proteins to phosphorylate GDP into GTP, or from an inactive state to an ...

; SOS2;

Human proteins containing this domain

References

Further reading