Railway Exchange Building may refer to the following:
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Railway Exchange Building (Chicago), Illinois, U.S., also called the Santa Fe Building, an office building
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Railway Exchange Building (Muskogee, Oklahoma), U.S., an eight-story office building
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Railway Exchange Building (Portland, Oregon), U.S., an historic building on the National Register of Historic Places
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Railway Exchange Building (St. Louis), Missouri, U.S., a 21-story office building
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