Radium chloride is an

inorganic compound An inorganic compound is typically a chemical compound that lacks carbon–hydrogen bonds⁠that is, a compound that is not an organic compound. The study of inorganic compounds is a subfield of chemistry known as ''inorganic chemistry''. Inorgan ...

with the

chemical formula A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as pare ...

. It is a

radium Radium is a chemical element; it has chemical symbol, symbol Ra and atomic number 88. It is the sixth element in alkaline earth metal, group 2 of the periodic table, also known as the alkaline earth metals. Pure radium is silvery-white, ...

salt of

hydrogen chloride The Chemical compound, compound hydrogen chloride has the chemical formula and as such is a hydrogen halide. At room temperature, it is a colorless gas, which forms white fumes of hydrochloric acid upon contact with atmospheric water vapor. Hyd ...

. It was the first

compound isolated in a pure state.

Marie Curie Maria Salomea Skłodowska-Curie (; ; 7 November 1867 – 4 July 1934), known simply as Marie Curie ( ; ), was a Polish and naturalised-French physicist and chemist who conducted pioneering research on radioactivity. She was List of female ...

and

André-Louis Debierne André-Louis Debierne (; 14 July 1874 – 31 August 1949) was a French chemist. He is often considered the discoverer of the element actinium, though H. W. Kirby disputed this in 1971 and gave credit instead to German chemist Friedrich Oskar Gies ...

used it in their original separation of radium from

barium Barium is a chemical element; it has symbol Ba and atomic number 56. It is the fifth element in group 2 and is a soft, silvery alkaline earth metal. Because of its high chemical reactivity, barium is never found in nature as a free element. Th ...

. The first preparation of radium metal was by the

electrolysis In chemistry and manufacturing, electrolysis is a technique that uses Direct current, direct electric current (DC) to drive an otherwise non-spontaneous chemical reaction. Electrolysis is commercially important as a stage in the separation of c ...

of a solution of this salt using a mercury cathode.

Preparation

Radium chloride crystallises from aqueous solution as the

dihydrate In chemistry, a hydrate is a substance that contains water or its constituent elements. The chemical state of the water varies widely between different classes of hydrates, some of which were so labeled before their chemical structure was understo ...

. The dihydrate is dehydrated by heating to 100 °C in air for one hour followed by 5.5 hours at 520 °C under

argon Argon is a chemical element; it has symbol Ar and atomic number 18. It is in group 18 of the periodic table and is a noble gas. Argon is the third most abundant gas in Earth's atmosphere, at 0.934% (9340 ppmv). It is more than twice as abu ...

. If the presence of other anions is suspected, the dehydration may be effectuated by fusion under

. Radium chloride can also be prepared by heating radium bromide in a flow of dry

gas. It can be produced by treating radium carbonate with hydrochloric acid.

Properties

Radium chloride is a colorless salt with a blue-green

luminescence Luminescence is a spontaneous emission of radiation from an electronically or vibrationally excited species not in thermal equilibrium with its environment. A luminescent object emits ''cold light'' in contrast to incandescence, where an obje ...

, especially when heated. Its color gradually changes to yellow with aging, whereas contamination by barium may impart a rose tint. It is less soluble in water than other

alkaline earth metal The alkaline earth metals are six chemical elements in group (periodic table), group 2 of the periodic table. They are beryllium (Be), magnesium (Mg), calcium (Ca), strontium (Sr), barium (Ba), and radium (Ra).. The elements have very similar p ...

chlorides – at 25 °C its solubility is 245 g/L whereas that of

barium chloride Barium chloride is an inorganic compound with the formula . It is one of the most common water-soluble salts of barium. Like most other water-soluble barium salts, it is a white powder, highly toxic, and imparts a yellow-green coloration to a flam ...

is 307 g/L, and the difference is even larger in hydrochloric acid solutions. This property is used in the first stages of the separation of radium from

by fractional crystallization. Radium chloride is only sparingly soluble in azeotropic

hydrochloric acid Hydrochloric acid, also known as muriatic acid or spirits of salt, is an aqueous solution of hydrogen chloride (HCl). It is a colorless solution with a distinctive pungency, pungent smell. It is classified as a acid strength, strong acid. It is ...

and virtually insoluble in concentrated hydrochloric acid. Gaseous shows strong absorptions in the visible spectrum at 676.3 nm and 649.8 nm (red): the dissociation energy of the radium–chlorine bond is estimated as 2.9 eV, and its

length Length is a measure of distance. In the International System of Quantities, length is a quantity with Dimension (physical quantity), dimension distance. In most systems of measurement a Base unit (measurement), base unit for length is chosen, ...

as 292 pm. Contrary to diamagnetic barium chloride, radium chloride is weakly

paramagnetic Paramagnetism is a form of magnetism whereby some materials are weakly attracted by an externally applied magnetic field, and form internal, induced magnetic fields in the direction of the applied magnetic field. In contrast with this behavior, ...

with a

magnetic susceptibility In electromagnetism, the magnetic susceptibility (; denoted , chi) is a measure of how much a material will become magnetized in an applied magnetic field. It is the ratio of magnetization (magnetic moment per unit volume) to the applied magnet ...

of 1.05. Its

flame color A flame test is relatively quick test for the presence of some elements in a sample. The technique is archaic and of questionable reliability, but once was a component of qualitative inorganic analysis. The phenomenon is related to pyrotechnics a ...

is red.

Uses

Radium chloride is still used for the initial stages of the separation of radium from barium during the extraction of radium from

pitchblende Uraninite, also known as pitchblende, is a radioactive, uranium-rich mineral and ore with a chemical composition that is largely UO2 but because of oxidation typically contains variable proportions of U3O8. Radioactive decay of the urani ...

. The large quantities of material involved (to extract a gram of pure radium metal, about 7 tonnes of pitchblende is required) favour this less costly (but less efficient) method over those based on radium bromide or radium chromate (used for the later stages of the separation). It was also used in

medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...

to produce

radon Radon is a chemical element; it has symbol Rn and atomic number 86. It is a radioactive noble gas and is colorless and odorless. Of the three naturally occurring radon isotopes, only Rn has a sufficiently long half-life (3.825 days) for it to b ...

gas which in turn was used as a brachytheraputic

cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

treatment. Radium-223 dichloride ( USP, radium chloride Ra 223), tradename Xofigo (formerly Alpharadin), is an alpha-emitting

radiopharmaceutical Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which ...

Bayer Bayer AG (English: , commonly pronounced ; ) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen, Bayer' ...

received FDA approval for this drug to treat

prostate cancer Prostate cancer is the neoplasm, uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of the prostate tissue is usually detected through Screening (medicine), screening tests, ...

osteoblastic bone metastases in May 2013. Radium-223 chloride is one of the most potent ((antineoplastic drugs)) known. One dose (50 kBq/kg) in an adult is about 60 nanograms; this amount is 1/1000 the weight of an eyelash (75 micrograms).

References

Bibliography

*''Gmelins Handbuch der anorganischen Chemie (8. Aufl.)'', Berlin:Verlag Chemie, 1928, pp. 60–61. * {{Chlorides Chlorides Alkaline earth metal halides Radium compounds