Pyrinuron (Pyriminil, Vacor) is a
chemical compound formerly used as a
rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the
Environmental Protection Agency
A biophysical environment is a biotic and abiotic surrounding of an organism or population, and consequently includes the factors that have an influence in their survival, development, and evolution. A biophysical environment can vary in scale f ...
for use in the United States.
If it is ingested by humans in high doses, it may selectively destroy insulin-producing
beta cells in the
pancreas causing
type 1 diabetes.
[ The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.]
References
Rodenticides
Ureas
3-Pyridyl compounds
Nitrobenzenes
{{organic-compound-stub