The purD RNA motif is a conserved

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

structure found in

Campylobacterota Campylobacterota are a phylum of bacteria. All species of this phylum are Gram-negative. The Campylobacterota consist of few known genera, mainly the curved to spirilloid '' Wolinella'' spp., '' Helicobacter'' spp., and ''Campylobacter'' spp. Mo ...

, such as the genera ''

Helicobacter ''Helicobacter'' is a genus of Gram-negative bacteria possessing a characteristic helical shape. They were initially considered to be members of the genus ''Campylobacter'', but in 1989, Goodwin ''et al.'' published sufficient reasons to justify ...

'' and ''

Campylobacter ''Campylobacter'' (meaning "curved bacteria") is a genus of Gram-negative bacteria. ''Campylobacter'' typically appear comma- or s-shaped, and are motile. Some ''Campylobacter'' species can infect humans, sometimes causing campylobacteriosis, a d ...

''. The RNA is consistently found in the apparent

5' UTR The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation o ...

of ''purD'' genes. ''purD'' genes encode the enzyme Phosphoribosylamine-glycine ligase, which catalyzes an early step in de novo

purine Purine is a heterocyclic aromatic organic compound that consists of two rings ( pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purin ...

synthesis. Although a possible ''cis''-regulatory role was proposed for this motif, experimental results indicate that it overlaps the

6S RNA In the field of molecular biology the 6S RNA is a non-coding RNA that was one of the first to be identified and sequenced. What it does in the bacterial cell was unknown until recently. In the early 2000s scientists found out the function of 6S ...

of the relevant species, and that the second

hairpin A hairpin or hair pin is a long device used to hold a person's hair in place. It may be used simply to secure long hair out of the way for convenience or as part of an elaborate hairstyle or coiffure. The earliest evidence for dressing the hai ...

of the motif might not be biological.

References

External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub