Proctosedyl is the brand name for a family of two products with identical
active ingredients designed to treat a variety of
proctological disorders. One is a
topical
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of class ...
ointment, the other a
rectal suppository. In the
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the European mainland, continental mainland. It comprises England, Scotlan ...
both products are contract manufactured by
Patheon Limited on behalf of the
Sanofi-Aventis
Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Originally, the corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Syn ...
group.
Manufacture and distribution is provided by Sanofi Aventis subsidiaries
in other territories worldwide.
Application
Both the yellowish-white, translucent, greasy ointment
and the smooth, off-white suppositories
are formulated for the relief of chronic
pruritus ani (otherwise known anal itching or anusitis)
and the treatment of pain, irritation, discharge and itching associated with
haemorrhoids (otherwise known as piles).
However both products are also used to provide pain relief in the treatment of
anal fissure,
for patients undergoing
haemorrhoidectomy, (pre and post-operative),
in the relief of
post-partum (otherwise known as post-natal) haemorrhoidal conditions,
and in the treatment of non-infective
proctitis.
Active ingredients
Both preparations contain:
*
Cinchocaine hydrochloride
Cinchocaine (INN/ BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia. It is sold under th ...
at a concentration of 5 mg/g
to provide
anaesthesia,
analgesia
Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professionals ...
and to act as a
spasmolytic.
*
Hydrocortisone
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, a ...
at a concentration of 5 mg/g.
to provide
antipruritic and
anti-inflammatory
Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs remedy pain by reducing inflammation as ...
relief
Preparations in some territories may also contain:
* Framycetin sulfate at a concentration of 10 mg/g
as an
antibacterial
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention ...
agent.
*
Aesculin at a concentration of 10 mg/g
for its retardant effect on
Escherichia coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Esc ...
(otherwise known as E. Coli).
References
{{Reflist
External links
Sanofi-AventisPatheon UK
Drugs acting on the gastrointestinal system and metabolism
Anesthesia
Glucocorticoids
Sanofi