Polyozellin is a chemical which occurs in the mushroom ''
Polyozellus multiplex
''Polyozellus multiplex'' is a species complex of fungi first described in 1899. ''P. multiplex'' is commonly known as the blue chanterelle, the purple chanterelle, or, in Alaska, the black chanterelle. However, this mushroom is not closel ...
''. It
inhibits prolyl endopeptidase
Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the ''PREP'' gene.
Function
Prolyl endopeptidase is a large cytosolic enzyme that belongs to a distinct cl ...
, an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that has a role in processing proteins (specifically,
amyloid precursor protein
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many biological tissue, tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of s ...
) in
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...
. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.
Structurally related
dibenzofuran
Dibenzofuran (DBF) is a heterocyclic organic compound with the chemical structure shown at right. It is an aromatic compound that has two benzene rings fused to a central furan ring. All the numbered carbon atoms have a hydrogen atom bonded to each ...
yl
derivatives of polyozellin are known as
kynapcins.
References
Dibenzofurans
Benzofuran ethers at the benzene ring
Acetate esters
Phenol esters
Hydroxyquinol ethers
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