Pirlimycin hydrochloride belongs to the
lincosamide class of
antimicrobials. Under the trade name Pirsue, it is used in the treatment of
mastitis in
cattle.
Activity
Pirlimycin is active against
Gram-positive bacteria
In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall.
Gram-positive bact ...
, specifically ''
Staphylococcus aureus
''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often positive ...
'' and
coagulase negative species of ''
Staphylococcus
''Staphylococcus'' is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillales. Under the microscope, they appear spherical (cocci), and form in grape-like clusters. ''Staphylococcus'' species are facultative ...
'' and ''
Streptococcus''. It has no activity against
Gram-negative bacteria.
Mechanism of action
It is
bacteriostatic and acts by inhibiting bacterial protein synthesis via binding with the
50S
The 50s decade ran from January 1, 50, to December 31, 59. It was the sixth decade in the Anno Domini/Common Era, if the nine-year period from 1 AD to 9 AD is considered as a "decade".
Significant people
* Claudius, Roman Emperor (AD 41� ...
subunit of the ribosome.
References
Lincosamides
Veterinary drugs
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