Phosphoramidon is a chemical compound derived from cultures of ''
Streptomyces tanashiensis
''Streptomyces tanashiensis'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from soil in Japan.Deutsche Sammlung von Mikroorganismen und Zellkulturen]/ref> ''Streptomyces tanashiensis'' produces luteomycin, mi ...
''. It is an
enzyme inhibitor, inhibitor of the
enzyme thermolysin,
of the
membrane metallo-endopeptidase,
[Phosphoramidon]
at PubChem and of the
endothelin converting enzyme
converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ''ECE1'' gene.
Function
Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 ( EDN2), and -3 (EDN3
Endoth ...
.
[ Chemically, phosphoramidon differs from its closely related peptidase inhibitor ]talopeptin
Talopeptin is a chemical compound derived from cultures of '' Streptomyces''. It is a known reversible inhibitor of thermolysin and is expected to inhibit other metalloproteinases. Chemically, talopeptin differs from its closely related peptida ...
by a single stereocenter.
Because of its enzyme inhibitory properties, phosphoramidon is widely used as a biochemical tool.
References
{{reflist
External links
* The MEROPS online database for peptidases and their inhibitors
Phosphoramidon
Hydrolase inhibitors
Phosphoramidates
Tryptamines