Pacer (also known as Rubicon-like) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the RUBCNL
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Pacer has been shown to increase cellular
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
through regulation of
PI3KC3.
Pacer contains a
Rubicon homology (RH) domain at its C-terminus, which mediates binding to
small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage.
This domain is shared with RH domain containing family members
Rubicon
The Rubicon (; ; ) is a shallow river in northeastern Italy, just south of Cesena and north of Rimini. It was known as ''Fiumicino'' until 1933, when it was identified with the ancient river Rubicon, crossed by Julius Caesar in 49 BC.
The ri ...
and
PLEKHM1.
Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
.
References
Further reading
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