Protein Serine/threonine-protein kinase H1 is a Ser/Thr

protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a f ...

that is encoded by the ''PSKH1''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the

Endoplasmic Reticulum The endoplasmic reticulum (ER) is a part of a transportation system of the eukaryote, eukaryotic cell, and has many other important functions such as protein folding. The word endoplasmic means "within the cytoplasm", and reticulum is Latin for ...

Interactions

PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

with (and be regulated by) proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and

calmodulin Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all Eukaryote, eukaryotic cells. It is an intracellular target of the Second messenger system, sec ...

. It is also activated by UNC119B, an acyl chain binding protein. PSKH1 is closely related to the catalytically-inactive

pseudokinase Pseudokinases are catalytically-deficient pseudoenzyme variants of protein kinases that are represented in all kinomes across the kingdoms of life. Pseudokinases have both physiological (signal transduction) and Pathophysiology, pathophysiological ...

PSKH2, which is also membrane-localised within the secretory pathway.

Interactions

References

Further reading