An oneirogen, from the

Greek Greek may refer to: Anything of, from, or related to Greece, a country in Southern Europe: *Greeks, an ethnic group *Greek language, a branch of the Indo-European language family **Proto-Greek language, the assumed last common ancestor of all kno ...

ὄνειρος ''óneiros'' meaning "

dream A dream is a succession of images, ideas, emotions, and sensation (psychology), sensations that usually occur involuntarily in the mind during certain stages of sleep. Humans spend about two hours dreaming per night, and each dream lasts around ...

" and ''gen'' "to create", is a substance that induces a dream-like state of consciousness. Oneirogens function by altering neural processing in a way that shifts the brain from bottom-up sensory input to top-down generative activity, resembling the mechanisms involved in dreaming. This neural shift is associated with increased internal imagery and reduced responsiveness to external stimuli. Psychedelics—particularly those acting on the

5-HT2A receptor The 5-HT2A receptor is a subtype of the 5-HT2 receptor, 5-HT2 receptor that belongs to the serotonin receptor family and functions as a GPCR, G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular ...

—produce oneirogenic effects by promoting this altered balance of neural signaling.

List of oneirogens

* '' Calea zacatechichi'' ("''Calea ternifolia''") has been traditionally used in

Central America Central America is a subregion of North America. Its political boundaries are defined as bordering Mexico to the north, Colombia to the southeast, the Caribbean to the east, and the Pacific Ocean to the southwest. Central America is usually ...

as a believed way to potentiate lucid dreams and perform dream

divination Divination () is the attempt to gain insight into a question or situation by way of an occultic ritual or practice. Using various methods throughout history, diviners ascertain their interpretations of how a should proceed by reading signs, ...

. It can promote dreams vivid to the senses, sight, scent, hearing, touch, and taste. May be taken as a tea or smoked. * '' Entada rheedii'' ("African dream bean") * Mugwort, see Artemisia douglasiana * '' Silene undulata'' (also known as "''Silene capensis''" or "''African dream root''") is used by the

Xhosa people The Xhosa people ( , ; ) are a Bantu peoples, Bantu ethnic group that migrated over centuries into Southern Africa eventually settling in South Africa. They are the second largest ethnic group in South Africa and are native speakers of the Xho ...

South Africa South Africa, officially the Republic of South Africa (RSA), is the Southern Africa, southernmost country in Africa. Its Provinces of South Africa, nine provinces are bounded to the south by of coastline that stretches along the Atlantic O ...

to induce lucid dreams. It has been found to contain β-carbolines and

ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...

List of possible oneirogens

Diphenhydramine Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. Although generally considered sedating, diphenhydramine can cause paradoxical central nervous system stimulation in some individuals, particula ...

("Benadryl") can invoke an intense hypnagogic REM-like

microsleep A microsleep is a sudden temporary episode of sleep or drowsiness which may last for a few seconds where an individual fails to respond to some arbitrary sensory input and becomes unconscious.International Classification of Sleep Disorders, , pa ...

often indifferentiable from reality. It accomplishes this by blocking various

acetylcholine receptor An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Classification Like other transmembrane receptors, acetylcholine receptor ...

s in the brain. *

Galantamine Galantamine is a type of acetylcholinesterase inhibitor. It is an alkaloid extracted from the bulbs and flowers of ''Galanthus nivalis'' (common snowdrop), '' Galanthus caucasicus'' (Caucasian snowdrop), '' Galanthus woronowii'' (Voronov's snow ...

was shown to increase lucid dreaming by 27% at 4 mg and 42% at 8 mg in a 2018 double-blind study lasting three nights. *

Ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...

Melatonin Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cow ...

and Ramelteon may cause vivid dreams as a side effect *

Mirtazapine Mirtazapine, sold under the brand name Remeron among others, is an atypical antidepressant, atypical tetracyclic antidepressant, and as such is used primarily to treat Depression (mood), depression. Its effects may take up to four weeks but ca ...

* Muscimol

Hallucinogenic oneirogens

* Tabernanthe iboga (iboga) is a

perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ...

rainforest Rainforests are forests characterized by a closed and continuous tree Canopy (biology), canopy, moisture-dependent vegetation, the presence of epiphytes and lianas and the absence of wildfire. Rainforests can be generally classified as tropi ...

shrub A shrub or bush is a small to medium-sized perennial woody plant. Unlike herbaceous plants, shrubs have persistent woody stems above the ground. Shrubs can be either deciduous or evergreen. They are distinguished from trees by their multiple ...

native to

West Africa West Africa, also known as Western Africa, is the westernmost region of Africa. The United Nations geoscheme for Africa#Western Africa, United Nations defines Western Africa as the 16 countries of Benin, Burkina Faso, Cape Verde, The Gambia, Gha ...

. An

evergreen In botany, an evergreen is a plant which has Leaf, foliage that remains green and functional throughout the year. This contrasts with deciduous plants, which lose their foliage completely during the winter or dry season. Consisting of many diffe ...

bush indigenous to

Gabon Gabon ( ; ), officially the Gabonese Republic (), is a country on the Atlantic coast of Central Africa, on the equator, bordered by Equatorial Guinea to the northwest, Cameroon to the north, the Republic of the Congo to the east and south, and ...

, the

Democratic Republic of Congo The Democratic Republic of the Congo (DRC), also known as the DR Congo, Congo-Kinshasa, or simply the Congo (the last ambiguously also referring to the neighbouring Republic of the Congo), is a country in Central Africa. By land area, it is t ...

, and the

Republic of Congo The Republic of the Congo, also known as Congo-Brazzaville, the Congo Republic or simply the Congo (the last ambiguously also referring to the neighbouring Democratic Republic of the Congo), is a country located on the western coast of Central ...

, it is cultivated across

. In African traditional medicine and

ritual A ritual is a repeated, structured sequence of actions or behaviors that alters the internal or external state of an individual, group, or environment, regardless of conscious understanding, emotional context, or symbolic meaning. Traditionally ...

s, the yellowish root or bark is used to produce

hallucination A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...

s and near-death outcomes, with some fatalities occurring. *

Psilocybe ''Psilocybe'' ( ) is a genus of gilled mushrooms, growing worldwide, in the family Hymenogastraceae. Many species contain the Psychedelic drug, psychedelic compounds psilocybin and psilocin. Taxonomy Taxonomic history A 2002 study of the ...

mushrooms and their active ingredients

psilocin Psilocin, also known as 4-hydroxy-''N'',''N''-dimethyltryptamine (4-HO-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocy ...

and

psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...

Disputed oneirogens

Valerian (herb) Valerian (''Valeriana officinalis'', Caprifoliaceae) is a perennial flowering plant native to Eurasia. It produces a catnip-like response in cats. Crude Extract, extracts of valerian root may have sedative and anxiolytic effects; however, the ...

– A study conducted in the UK in 2001 showed that valerian root significantly improved stress induced insomnia, but as a side effect greatly increased the vividness of dreams. This study concluded that valerian root affects REM due to natural chemicals and essential oils that stimulate serotonin and opioid receptors. Another study found no encephalographic changes in subjects under its influence.

Nonchemical oneirogens

Mindfulness Mindfulness is the cognitive skill, usually developed through exercises, of sustaining metacognitive awareness towards the contents of one's own mind and bodily sensations in the present moment. The term ''mindfulness'' derives from the Pali ...

practices could be useful in achieving lucid dream. *

Sleep deprivation Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health. It can be either Chronic (medicine), chronic ...

can make dreams more intense, which is caused by REM rebound effect

References

Sources

* *

External links

* {{Hallucinogens Dream