In
virology
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, th ...
, a nonstructural protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
encoded by a
virus
A virus is a wikt:submicroscopic, submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and ...
but that is not part of the viral particle.
They typically include the various
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
s and
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s the virus uses to replicate itself, such as a
viral protease (
3CL/nsp5, etc.), an
RNA replicase or other template-directed polymerases, and some means to control the host.
Examples
*
NSP1 (rotavirus)
*
NSP4 (rotavirus)
The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It is a viroporin and induces diarrhea and causes Ca2+-dependent transepithelial secretion.
A transmembrane glycoprotein, NSP4 is organized into three main dom ...
*
NSP5 (rotavirus)
*
Influenza non-structural protein
*
NS1 influenza protein
*
HBcAg
HBcAg (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).
Structure ...
, core antigen of
hepatitis B
Hepatitis B is an infectious disease caused by the '' Hepatitis B virus'' (HBV) that affects the liver; it is a type of viral hepatitis. It can cause both acute and chronic infection.
Many people have no symptoms during an initial infection. F ...
*
Bunyaviridae nonstructural S proteins
''Bunyaviridae'' nonstructural S proteins (NSs) are synthesized by viral DNA/RNA and do not play a role in the replication or the viral protein coating. The nonstructural S segment (NSs) created by ''Bunyaviridae'' virus family'','' are able to i ...
See also
*
Viral structural protein
References
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