A nonsteroidal compound is a drug that is not a
steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.
Steroids have two principal biological functions: as important components of cell membranes t ...
nor a steroid derivative.
Nonsteroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs (NSAID) are members of a Indication (medicine), therapeutic drug class which Analgesic, reduces pain, Anti-inflammatory, decreases inflammation, Antipyretic, decreases fever, and Antithrombotic, prevents bl ...
s (NSAIDs) are distinguished from
corticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...
s as a class of
anti-inflammatory agents.
List of nonsteroidal steroid receptor modulators
Examples include the following:
*
Estrogen
Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three ...
s:
benzestrol,
bifluranol,
estrobin (DBE),
diethylstilbestrol (stilbestrol),
dienestrol,
erteberel
Erteberel (, ; former developmental code name LY-500307; also known as selective estrogen receptor beta agonist-1 or SERBA-1) is a synthetic, nonsteroidal estrogen which acts as a selective ERĪ² agonist and was under development by Eli Lilly fo ...
,
fosfestrol,
hexestrol (dihydroxystilbestrol),
methallenestril,
methestrol,
methestrol dipropionate,
paroxypropione,
prinaberel
Prinaberel (International Nonproprietary Name, INN, United States Adopted Name, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic compound, synthetic, nonsteroidal, and highly binding selectivity, selective agonist of the estrog ...
, and
triphenylethylene, as well as many
xenoestrogens
* :
acolbifene,
afimoxifene,
arzoxifene,
bazedoxifene,
broparestrol,
chlorotrianisene,
clomifene,
clomifenoxide,
cyclofenil,
droloxifene,
enclomifene,
endoxifen,
ethamoxytriphetol,
fispemifene,
idoxifene,
lasofoxifene,
levormeloxifene,
miproxifene,
nafoxidine,
nitromifene,
ormeloxifene,
ospemifene,
panomifene,
pipendoxifene,
raloxifene,
tamoxifen
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome ...
,
toremifene,
trioxifene,
zindoxifene,
zuclomifene
*
Antiandrogens:
apalutamide,
bicalutamide,
cimetidine
Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is mainly used in the treatment of heartburn and peptic ulcers.
With the development of proton pump ...
,
darolutamide,
DIMP,
enzalutamide,
EPI-001
EPI-001 is the first inhibitor of the androgen receptor amino-terminal domain. The single stereoisomer of EPI-001, EPI-002, is a first-in-class drug that the USAN council assigned a new stem class "-aniten" and the generic name "ralaniten". This ...
,
EPI-506,
flutamide,
hydroxyflutamide,
inocoterone,
inocoterone acetate,
nilutamide,
RU-58642,
RU-58841, and
topilutamide
* :
AC-262,356,
acetothiolutamide,
andarine,
BMS-564,929,
enobosarm (ostarine),
LGD-2226,
LGD-3303,
LGD-4033,
S-23, and
S-40503
*
Aromatase inhibitors:
anastrozole,
aminoglutethimide
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications. ...
,
fadrozole,
finrozole,
letrozole,
liarozole,
norendoxifen,
rogletimide (pyridoglutethimide),
vorozole
* Other
steroidogenesis inhibitor
A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid ho ...
s:
aminoglutethimide
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications. ...
,
ketoconazole
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal drug, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin inf ...
,
orteronel
Orteronel (TAK-700) is a nonsteroidal CYP17A1 inhibitor that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals. It completed two phase III clinical trials for meta ...
,
seviteronel
__NOTOC__
Seviteronel (developmental codes VT-464 and, formerly, INO-464) is an experimental cancer medication which is under development by Viamet Pharmaceuticals and Innocrin Pharmaceuticals for the treatment of prostate cancer and breast canc ...
, others
* Miscellaneous:
tanaproget (
progestogen),
finerenone (
antimineralocorticoid),
esaxerenone (antimineralocorticoid),
apararenone (antimineralocorticoid),
AZD5423 (
glucocorticoid
Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebra ...
),
mapracorat ()
See also
*
Nonsteroidal antiandrogen
A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure. They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens lik ...
*
Nonsteroidal estrogen
References
Further reading
*
*
*
Pharmacology
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