Nardosinone is a

sesquiterpene Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many combinations. Biochemical modifications s ...

and chemical constituent of ''

Nardostachys jatamansi ''Nardostachys'' is a genus of flowering plant in the honeysuckle family (Caprifoliaceae). ''Nardostachys jatamansi'' is the sole species in genus. It is a perennial that grows in the Himalayas, primarily in a belt through Kumaon, Nepal, Sikk ...

''. In ''

in vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...

'' studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced

neurite A neurite or neuronal process refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture ...

outgrowth. Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and

synaptogenesis Synaptogenesis is the formation of synapses between neurons in the nervous system. Although it occurs throughout a healthy person's lifespan, an explosion of synapse formation occurs during early brain development, known as exuberant synaptogene ...

from PC12D cells. Additionally, nardosinone has demonstrated

cytotoxic Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance. Also some types of dr ...

activity against cultured P-388 lymphocytic leukemia cells.

References

{{reflist Phytochemicals Sesquiterpenes Organic peroxides Enones Oxygen heterocycles Heterocyclic compounds with 3 rings