NEDD8 ultimate buster 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''NUB1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a
ubiquitin-like protein
Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in a cell (biology), cell, usually with a regulatory protein, regulatory function. The UBL protein family derives its name ...
that covalently conjugates to cullin (see MIM 603134) family members.
upplied by OMIMref name="entrez"/>
Interactions
NUB1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
NEDD8
NEDD8 is a protein that in humans is encoded by the ''NEDD8'' gene. (in ''Saccharomyces cerevisiae'' this protein is known as Rub1) This ubiquitin-like protein, ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cell ...
,
[ and ]AIPL1
Aryl-hydrocarbon-interacting protein-like 1 is a protein that in humans is encoded by the ''AIPL1'' gene. The protein is a member of FKBP prolyl isomerase family.
Function
Leber congenital amaurosis (LCA) accounts for at least 5% of all inh ...
.
References
Further reading
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