The Microbicide Trials Network (MTN, 2006-2021) was a United States government-funded research organization working in the field of
microbicides for sexually transmitted diseases.
The MTN focused on research into microbicides which would prevent
HIV
The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the im ...
infection. The MTN was a member of
HANC. After its closure, partner organization
HIV Prevention Trials Network
The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prev ...
took control of its projects.
Research
The MTN's notable research included various
clinical trials
Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...
.
The results of the
CAPRISA 004 trial inspired the research of the MTN and the microbicide field.
The Vaginal and Oral Interventions to Control the Epidemic (VOICE) found a vaginal gel containing an anti-HIV drug to be ineffective at preventing HIV transmission..
The HOPE study tested
dapivirine
Dapivirine is a non-nucleoside reverse transcriptase inhibitor developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides has held exclusive worldwide rights to dapivirine since 2014, buil ...
vaginal rings for HIV prevention in 1,456 study participants at 14 sites in Malawi, South Africa, Uganda and Zimbabwe.
References
External links
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{{Microbicides for sexually transmitted diseases
HIV/AIDS organizations in the United States
Medical and health organizations based in Pennsylvania
Microbicides
Defunct organizations based in the United States