Metergoline (, ), also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a
monoaminergic medication of the
ergoline group which is used as a
prolactin inhibitor
A prolactin modulator is a drug which affects the hypothalamic–pituitary–prolactin axis (HPP axis) by modulating the secretion of the pituitary hormone prolactin from the anterior pituitary gland. ''Prolactin inhibitors'' suppress and ''prolac ...
in the treatment of
hyperprolactinemia (high
prolactin levels) and to suppress
lactation.
Pharmacology
Pharmacodynamics
Metergoline is a
ligand of various
serotonin
Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...
and
dopamine receptors.
References
External links
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{{Ergolines
Antipsychotics
Carbamates
Dopamine agonists
Ergolines
Prolactin inhibitors
Serotonin receptor antagonists