Maddika Subba Reddy is an Indian

cell biologist Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...

and the head of the Laboratory of Cell Death and Cell Survival (LCDCS) of the Centre for DNA Fingerprinting and Diagnostics. A Wellcome- DBT Senior Fellow, Reddy is known for his studies

cell signaling In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biol ...

and

phosphatase In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid Ester, monoester into a phosphate ion and an Alcohol (chemistry), alcohol. Because a phosphatase enzyme catalysis, catalyzes the hydrolysis of its Substrate ...

s. The

Department of Biotechnology The Department of Biotechnology (DBT) is an Indian government department, under the Ministry of Science and Technology responsible for administrating development and commercialisation in the field of modern biology and biotechnology in India. ...

of the Government of India awarded him the

National Bioscience Award for Career Development The National Bio-science Award for Career Development or N-BIOS Prize is an Indian science award for recognizing excellence and promoting research in bio-sciences disciplines. It was instituted in 1999 by the Department of Biotechnology of the Gov ...

, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18.

Biography

Maddika Subba Reddy secured his PhD in Biochemistry and Medical Genetics from the

University of Manitoba The University of Manitoba (U of M, UManitoba, or UM) is a public research university in Winnipeg, Manitoba, Canada. Founded in 1877, it is the first university of Western Canada. Both by total student enrolment and campus area, the University of ...

in 2007. His post-doctoral training was at the laboratory of Junjie Chen of

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

and on his return to India in 2009, he joined the Centre for DNA Fingerprinting and Diagnostics (CDFD) where he heads the Laboratory of Cell Death and Cell Survival (LCDCS). A

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...

- DBT India Alliance senior fellow since 2016, Reddy is known for his studies on cellular

phosphatases In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Pho ...

and cellular signaling pathways. The team led by Reddy is credited with the identification of NEDD4-like E3 ubiquitin-protein ligase WWP2, an

E3 ligase A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin ...

, as a regulator for PTEN, a

tumor suppressor gene A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell (biology), cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results ...

and the discovery is reported to have significance in controlling cell proliferation, thereby in controlling cancer. He has published a number of articles;

ResearchGate ResearchGate is a European commercial social networking site for scientists and researchers to share papers, ask and answer questions, and find collaborators. According to a 2014 study by ''Nature'' and a 2016 article in ''Times Higher Education' ...

, an online repository of scientific articles has listed 77 of them.

Awards and honors

The

of the Government of India awarded him the

, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18. An elected member of the Guha Research Conference and a former young associate of the

Indian Academy of Sciences The Indian Academy of Sciences, Bangalore was founded by Indian Physicist and List of Nobel laureates, Nobel Laureate Chandrasekhara Venkata Raman, C. V. Raman, and was registered as a society on 27 April 1934. Inaugurated on 31 July 1934, it ...

, he is also a recipient of the

NASI Nasi may refer to: Food Dishes Nasi Goreng is an Indonesian and Malay word for ''cooked rice'', featured in many Southeast Asian dishes *Nasi goreng, a popular rice dish often simply called ''nasi'' *Other Southeast Asian ''nasi'' dishes: ** Nasi ...

-Scopus Young Scientist Award of the

Elsevier Elsevier ( ) is a Dutch academic publishing company specializing in scientific, technical, and medical content. Its products include journals such as ''The Lancet'', ''Cell (journal), Cell'', the ScienceDirect collection of electronic journals, ...

and

National Academy of Sciences, India The National Academy of Sciences, India, also known as NASI, was established in 1930 and is the oldest science academy of India. It is located in Prayagraj, Uttar Pradesh. Prof. Meghnad Saha was the founder president. Fellows * Suddhasatwa Bas ...

for the year 2017.

Selected bibliography

* * * * *

Notes

References

External links

* {{DEFAULTSORT:Reddy, Maddika Subba Year of birth missing (living people) N-BIOS Prize recipients Indian cell biologists Yale University alumni University of Manitoba alumni Living people