MYCO-005 is a

serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT_2A receptor

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

and

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

hallucinogen Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ...

which is under development for the treatment of

depressive disorder A mood disorder, also known as an affective disorder, is any of a group of conditions of mental disorder, mental and Abnormal behavior, behavioral Disorder (medicine), disorder where the main underlying characteristic is a disturbance in the per ...

s and

anxiety disorder Anxiety disorders are a group of mental disorders characterized by significant and uncontrollable feelings of anxiety and fear such that a person's social, occupational, and personal functions are significantly impaired. Anxiety may cause phys ...

s. It is an

aza Aza or AZA may refer to: Places *Aza, Azerbaijan, a village and municipality *Azadkənd, Nakhchivan or Lower Aza, Azerbaijan *Aza, medieval name of Haza, Province of Burgos, Spain *Aźa, a Tibetan name for the Tuyuhun kingdom *Aza, a Hebrew roman ...

indole Indole is an organic compound with the formula . Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole ...

analogue of

psilocin Psilocin, also known as 4-hydroxy-''N'',''N''-dimethyltryptamine (4-HO-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocy ...

and hence a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...

relative. However, whereas psilocin and other tryptamines show high

affinity Affinity may refer to: Commerce, finance and law * Affinity (law), kinship by marriage * Affinity analysis, a market research and business management technique * Affinity Credit Union, a Saskatchewan-based credit union * Affinity Equity Pa ...

for and potent activation of not only the serotonin 5-HT_2A receptor but also the serotonin 5-HT_2B receptor, MYCO-005 does not bind to this receptor. Activation of the serotonin 5-HT_2B receptor is known to induce the development of

cardiac valvulopathy Cardiac fibrosis commonly refers to the excess deposition of extracellular matrix in the cardiac muscle, but the term may also refer to an abnormal thickening of the heart valves due to inappropriate proliferation of cardiac fibroblasts. Fibrotic c ...

and has been a concern with regard to chronic

microdosing Microdosing, or micro-dosing, involves the administration of sub-therapeutic doses of drugs to study their effects in humans, aiming to gather preliminary data on safety, pharmacokinetics, and potential therapeutic benefits without producing s ...

of psychedelics. Since MYCO-005 does not activate the serotonin 5-HT_2B receptor, it is anticipated to be

heart The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...

-safe and to be safer for use in the contexts of both macro- and microdosing than other psychedelics. As of February 2024, MYCO-005 is in the research stage of development for depressive disorders and anxiety disorders. It is being developed by

Mydecine Mydecine Innovations Group, or simply Mydecine, is an United States, American and Canada, Canadian pharmaceutical company that is developing psychedelic drug, psychedelics and entactogens as medicines. In August 2022, it was reported that Mydecin ...

. The exact

chemical structure A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds. Its determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target m ...

of MYCO-005 does not yet seem to have been disclosed. However, the compound was

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

ed in 2023 and the specified patent specifically describes

substituted Substitution may refer to: Arts and media *Substitution (poetry), a variation in poetic scansion *Substitution (theatre), an acting methodology Music *Chord substitution, swapping one chord for a related one within a chord progression *Tritone ...

psilocin analogues.

References

{{Serotonin receptor modulators 5-HT2A agonists Drugs with undisclosed chemical structures Experimental drugs Experimental hallucinogens Psychedelic drugs Serotonin receptor agonists

See also

References