MRZ-9547, also known as (''R'')-phenylpiracetam, (''R'')-phenotropil, or (''R'')-fonturacetam, is a selective

dopamine reuptake inhibitor A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dop ...

( = 14.5μM) that was developed by Merz Pharma. It is the (''R'')-

enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...

of the

racetam Racetams, also sometimes known simply as pyrrolidones, are a class of drugs that share a pyrrolidone nucleus. Many, but not all, specifically have a 2- oxo-1- pyrrolidine acetamide (piracetam) nucleus. Some racetams, such as piracetam, aniracet ...

and

nootropic Nootropics ( or ) (colloquially brain supplements, smart drugs, cognitive enhancers, memory enhancers, or brain boosters) are chemical substances which purportedly improve cognitive functions, such as attention, memory, wakefulness, and self ...

phenylpiracetam Phenylpiracetam, also known as fonturacetam () and sold under the brand names Phenotropil, Actitropil, and Carphedon among others, is a psychostimulant, stimulant and nootropic medication used in Russia and certain other Eastern European countr ...

(phenotropil; fonturacetam). The drug was under development for the treatment of

fatigue Fatigue is a state of tiredness (which is not sleepiness), exhaustion or loss of energy. It is a signs and symptoms, symptom of any of various diseases; it is not a disease in itself. Fatigue (in the medical sense) is sometimes associated wit ...

associated with

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...

and was in phase 1

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s for this indication in June 2014. However, no recent development has been reported as of November 2017. There was also interest in MRZ-9547 for treatment of fatigue in people with depression and other conditions, but this was not pursued. Similarly to other dopamine reuptake inhibitors and related agents, MRZ-9547 has been found to have pro-motivational effects in animals and to reverse motivational deficits induced by the

dopamine depleting agent Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmittersserotonin, dopamine, and norepinephrine. One mechanism by which these agents act is by inhibiting reuptake by the vesicular m ...

tetrabenazine Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the US Food and Drug Administration (FDA) approved the use of tet ...

. The drug, as the

enantiopure In chemistry, an enantiomer ( /ɪˈnænti.əmər, ɛ-, -oʊ-/ ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities which are mirror images of each other and non-superpos ...

(''R'')-enantiomer of phenylpiracetam, was first described in the

scientific literature Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical ...

by 2014.

References

Abandoned drugs Acetamides Dopamine reuptake inhibitors Enantiopure drugs Nicotinic agonists Phenyl compounds Pro-motivational agents Racetams {{Nervous-system-drug-stub

See also

References