ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the

TRPML TRPML (transient receptor potential cation channel, mucolipin subfamily) comprises a group of three evolutionarily related proteins that belongs to the large family of transient receptor potential ion channels. The three proteins TRPML1, TRPML2 ...

family of calcium channels, with greatest activity at the

TRPML1 Mucolipin-1 also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the ''MCOLN1'' gene. It is a member of the small family of the TRPML channels, a subgroup of ...

channel, although it also blocks the related

TRPML2 Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the ''MCOLN2'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined th ...

and

TRPML3 Mucolipin-3 also known as TRPML3 (transient receptor potential cation channel, mucolipin subfamily, member 3) is a protein that in humans is encoded by the ''MCOLN3'' gene. It is a member of the small family of the TRPML channels, a subgroup o ...

channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in

lysosome A lysosome () is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane ...

s and elsewhere in the body.

References

{{Transient receptor potential channel modulators Sulfonamides Phenylpiperazines

See also

References