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MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a
MDPHP acts as a potent norepinephrine-dopamine reuptake inhibitor. The IC50 values for MDPHP are 0.06 μM at NET, 0.05 μM at DAT and 9 μM at SERT.
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
of the cathinone
Cathinone (; also known as β-ketoamphetamine) is a monoamine alkaloid found in the shrub ''Catha edulis'' (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to t ...
class originally developed in the 1960s, which has been reported as a novel designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
. In the UK its slang name is ''monkey dust''. It is closely related to the potent stimulant MDPV
Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ing ...
though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.
Pharmacology
MDPHP acts as a potent norepinephrine-dopamine reuptake inhibitor. The IC50 values for MDPHP are 0.06 μM at NET, 0.05 μM at DAT and 9 μM at SERT.
Legal status
MDPHP is specifically listed as a controlled substance in Japan and Hungary, and is controlled under analogue provisions in a number of other jurisdictions.Documented fatalities
A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital. Another case has been reported, involving a 30-years-old male cocaine consumer, found dead on July 20th, 2023, in Florence, Italy.See also
* α-Pyrrolidinohexiophenone (α-PHP) *3',4'-Methylenedioxy-α-pyrrolidinopropiophenone
3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills. It shares a similar chemical structure with α-P ...
(MDPPP)
* 3F-PHP
3-Fluoro-alpha-PHP (3F-PHP) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It was first identified in Sweden in 2020 and continues to be detected in seized drug samples, though it appears to ...
* 4F-PHP
4-Fluoro-alpha-PHP (4F-PHP) is a recreational designer drug from the substituted cathinone family with stimulant effects, which first appeared on the illicit market in around 2017. This compound is structurally related to other well-known stimula ...
* 4-Cl-PHP
4-Chloro-alpha-Pyrrolidinohexiophenone (4-Cl-PHP) is a substituted cathinone derivative with stimulant effects, which has been sold as a designer drug. It was first officially identified by forensic laboratories in 2016, though anecdotal reports ...
* 5-BPDi
* N-Ethylhexedrone
''N''-Ethylhexedrone (also known as α-ethylaminocaprophenone, ''N''-ethylnorhexedrone, hexen, and NEH) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI) with IC50 inhibition values of 0.09 ...
* N-Ethylhexylone
* MDPEP
MDPEP (also known as MD-PV8 and MDPHPP) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It is the longer chain heptyl Homologous series, homologue of the well known stimulant designer drugs MD ...
References
Butyl compounds Designer drugs Methylenedioxyphenethylamines Pyrrolidinophenones {{nervous-system-drug-stub