MAGOH
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Protein mago nashi homolog is a human
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
encoded by the ''MAGOH''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
. This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the
germplasm Germplasm refers to genetic resources such as seeds, tissues, and DNA sequences that are maintained for the purpose of animal and plant breeding, conservation efforts, agriculture, and other research uses. These resources may take the form of s ...
, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent
fibroblasts A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibrobla ...
.


In Drosophila

Drosophila flies produce unfit progeny when they have mutations in their gene. The progeny have defects in germplasm assembly and germline development.


Interactions

MAGOH interacts with
RBM8A RNA-binding protein 8A is a protein that in humans is encoded by the ''RBM8A'' gene. This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. ...
and
NXF1 Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the ''NXF1'' gene. Function This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a n ...
. In
Drosophila melanogaster ''Drosophila melanogaster'' is a species of fly (an insect of the Order (biology), order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly", "pomace fly" ...
, Mago Nashi and Tsunagi/ Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which is involved in oocyte differentiation.


References


Further reading

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