Lys-MDA (Lysine-MDA, N-(L-lysinamidyl)-3,4-methylenedioxyamphetamine) is a

substituted amphetamine Substituted amphetamines, or simply amphetamines, are a chemical class, class of compounds based upon the amphetamine structure; it includes all derivative (chemistry), derivative compounds which are formed by replacing, or substitution reacti ...

derivative with

empathogen Entactogens, also known as empathogens or connectogens, are a class of psychoactive drugs that induce the production of experiences of emotional communion, oneness, connectedness, emotional openness—that is, empathy—as particularly observe ...

ic effects, which acts as a

prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ...

for

MDA MDA, mda or variants may refer to: Businesses and organizations Political parties * Meghalaya Democratic Alliance (2003–2008), in India * Meghalaya Democratic Alliance (2018–present), in India * Movement for Democracy in Africa, in Burkina F ...

with a slower onset of effects and longer duration of action. Lys-MDA, along with the related derivative

Lys-MDMA Lys-MDMA, or lysine-MDMA, also known as ''N''-(L-lysinamidyl)-MDMA, is a prodrug of MDMA which is being investigated for possible use as a pharmaceutical drug in the treatment of psychiatric disorders. Structurally, lys-MDMA is to MDMA as lisdexa ...

, are in early stage human

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s as potential treatments for

treatment-resistant depression Treatment-resistant depression (TRD) is often defined as major depressive disorder in which an affected person does not respond adequately to at least two different antidepressant medications at an adequate dose and for an adequate duration. Inad ...

and

post-traumatic stress disorder Post-traumatic stress disorder (PTSD) is a mental disorder that develops from experiencing a Psychological trauma, traumatic event, such as sexual assault, domestic violence, child abuse, warfare and its associated traumas, natural disaster ...

. New

MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...

prodrugs are in the development phase at

MiHKAL GmbH MiHKAL GmbH, with MiHKAL being an acronym of Molecules I Have Known and Loved, is a Swiss pharmaceutical company that is developing psychedelics and entactogens as potential medicines. Matthias Grill is the founder and chief executive officer (CE ...

in Switzerland. A phase 1

comparing MDMA, MDA, Lys-MDMA, and Lys-MDA has been completed as of August 2024.

References

{{Monoamine releasing agents Designer drugs Entactogens Experimental entactogens Methylenedioxyphenethylamines Prodrugs Psychedelic phenethylamines Serotonin-norepinephrine-dopamine releasing agents Substituted amphetamines

See also

References