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Liquorice (
Commonwealth English The use of the English language in current and former Member states of the Commonwealth of Nations, countries of Commonwealth of Nations, the Commonwealth was largely inherited from British Empire, British colonisation, with some exceptions. Eng ...
) or licorice (
American English American English, sometimes called United States English or U.S. English, is the set of variety (linguistics), varieties of the English language native to the United States. English is the Languages of the United States, most widely spoken lang ...
; see
spelling differences Despite the various English dialects spoken from country to country and within different regions of the same country, there are only slight regional variations in English orthography, the two most notable variations being British and Americ ...
; ) is the
common name In biology, a common name of a taxon or organism (also known as a vernacular name, English name, colloquial name, country name, popular name, or farmer's name) is a name that is based on the normal language of everyday life; and is often con ...
of ''Glycyrrhiza glabra'', a
flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (). The term angiosperm is derived from the Ancient Greek, Greek words (; 'container, vessel') and (; 'seed'), meaning that the seeds are enclosed with ...
of the bean family
Fabaceae Fabaceae () or Leguminosae,International Code of Nomen ...
, from the root of which a sweet, aromatic flavouring is
extract An extract (essence) is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures or absolutes or dried and powdered. The aromatic principles of ma ...
ed. The liquorice plant is an
herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of ...
perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ...
legume Legumes are plants in the pea family Fabaceae (or Leguminosae), or the fruit or seeds of such plants. When used as a dry grain for human consumption, the seeds are also called pulses. Legumes are grown agriculturally, primarily for human consum ...
native to
West Asia West Asia (also called Western Asia or Southwest Asia) is the westernmost region of Asia. As defined by most academics, UN bodies and other institutions, the subregion consists of Anatolia, the Arabian Peninsula, Iran, Mesopotamia, the Armenian ...
,
North Africa North Africa (sometimes Northern Africa) is a region encompassing the northern portion of the African continent. There is no singularly accepted scope for the region. However, it is sometimes defined as stretching from the Atlantic shores of t ...
, and
Southern Europe Southern Europe is also known as Mediterranean Europe, as its geography is marked by the Mediterranean Sea. Definitions of southern Europe include some or all of these countries and regions: Albania, Andorra, Bosnia and Herzegovina, Bulgaria, C ...
. Liquorice is used as a flavouring in confectionery,
tobacco Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
, beverages, and
pharmaceuticals Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the ...
, and is marketed as a
dietary supplement A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill (pharmacy), pill, capsule (pharmacy), capsule, tablet (pharmacy), tablet, powder, or liquid. A supplement can provide nutrients eithe ...
. Liquorice extracts have been used in
herbalism Herbal medicine (also called herbalism, phytomedicine or phytotherapy) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. Scientific evidence for the effectiveness of many herbal treatments ...
and
traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) refers to the knowledge, skills, and practices rooted in the cultural beliefs of various societies, especially Indigenous groups, used for maintaining health and treatin ...
. Excessive consumption of liquorice (more than per day of pure
glycyrrhizinic acid Glycyrrhizin (glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' (liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmetics. I ...
, a key component of liquorice) can lead to undesirable consequences. Clinically, it is suspected that overindulgence in liquorice may manifest as unexplained
hypertension Hypertension, also known as high blood pressure, is a Chronic condition, long-term Disease, medical condition in which the blood pressure in the artery, arteries is persistently elevated. High blood pressure usually does not cause symptoms i ...
, low blood potassium levels (
hypokalemia Hypokalemia is a low level of potassium (K+) in the blood serum. Mild low potassium does not typically cause symptoms. Symptoms may include feeling tired, leg cramps, weakness, and constipation. Low potassium also increases the risk of an a ...
), and muscle weakness in individuals. Consuming liquorice should be avoided during pregnancy.


Etymology

The word ''
liquorice Liquorice ( Commonwealth English) or licorice (American English; see spelling differences; ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is ...
'' (UK, CAN), or ''
licorice Liquorice (Commonwealth English) or licorice (American English; see spelling differences; ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is ...
'' (US), is derived via the Anglo-French , from
Late Latin Late Latin is the scholarly name for the form of Literary Latin of late antiquity.Roberts (1996), p. 537. English dictionary definitions of Late Latin date this period from the 3rd to 6th centuries CE, and continuing into the 7th century in ...
, itself ultimately derived from Greek (the
Modern Greek Modern Greek (, or , ), generally referred to by speakers simply as Greek (, ), refers collectively to the dialects of the Greek language spoken in the modern era, including the official standardized form of the language sometimes referred to ...
spelling of the genus is ) literally meaning 'sweet root' and referring to ''Glycyrrhiza glabra''. The latter gives the plant
binomial name In taxonomy, binomial nomenclature ("two-term naming system"), also called binary nomenclature, is a formal system of naming species of living things by giving each a name composed of two parts, both of which use Latin grammatical forms, altho ...
with ''glabra'' meaning ''smooth'' and referring to the plant's smooth husks; the former came to being via the influence of , 'to become fluid', reflecting the method of extracting the sweet component from the roots. , its English common name is spelled 'liquorice' in most of the
Commonwealth A commonwealth is a traditional English term for a political community founded for the common good. The noun "commonwealth", meaning "public welfare, general good or advantage", dates from the 15th century. Originally a phrase (the common-wealth ...
, but 'licorice' is also used in some countries.


Description

Liquorice is a
herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of ...
perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ...
, growing to in height, with
pinnate Pinnation (also called pennation) is the arrangement of feather-like or multi-divided features arising from both sides of a common axis. Pinnation occurs in biological morphology, in crystals, such as some forms of ice or metal crystals, and ...
leaves A leaf (: leaves) is a principal appendage of the stem of a vascular plant, usually borne laterally above ground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", while the leaves, stem, ...
about long, with 9–17 leaflets. The
flower Flowers, also known as blooms and blossoms, are the reproductive structures of flowering plants ( angiosperms). Typically, they are structured in four circular levels, called whorls, around the end of a stalk. These whorls include: calyx, m ...
s are long, purple to pale whitish blue, produced in a loose
inflorescence In botany, an inflorescence is a group or cluster of flowers arranged on a plant's Plant stem, stem that is composed of a main branch or a system of branches. An inflorescence is categorized on the basis of the arrangement of flowers on a mai ...
. The
fruit In botany, a fruit is the seed-bearing structure in flowering plants (angiosperms) that is formed from the ovary after flowering. Fruits are the means by which angiosperms disseminate their seeds. Edible fruits in particular have long propaga ...
is an oblong pod, long, containing several
seed In botany, a seed is a plant structure containing an embryo and stored nutrients in a protective coat called a ''testa''. More generally, the term "seed" means anything that can be Sowing, sown, which may include seed and husk or tuber. Seeds ...
s.Huxley, A., ed. (1992). ''New RHS Dictionary of Gardening''. The roots are
stoloniferous In biology, a stolon ( from Latin '' stolō'', genitive ''stolōnis'' – "branch"), also known as a runner, is a horizontal connection between parts of an organism. It may be part of the organism, or of its skeleton. Typically, animal stolons ar ...
.


Chemistry

Liquorice root contains
triterpenoids Triterpenes are a class of terpenes composed of six isoprene units with the molecular formula C30H48; they may also be thought of as consisting of three terpene units. Animals, plants and fungi all produce triterpenes, including squalene, the pre ...
,
polyphenol Polyphenols () are a large family of naturally occurring phenols. They are abundant in plants and structurally diverse. Polyphenols include phenolic acids, flavonoids, tannic acid, and ellagitannin, some of which have been used historically as ...
s, and
polysaccharide Polysaccharides (), or polycarbohydrates, are the most abundant carbohydrates found in food. They are long-chain polymeric carbohydrates composed of monosaccharide units bound together by glycosidic linkages. This carbohydrate can react with wat ...
s.
Flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...
s account for the yellow root color. The principal
glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...
, glycyrrhizin, exists in content of 7% to 10%, depending on cultivation practices. The isoflavene
glabrene Glabrene is an isoflavonoid that is found in ''Glycyrrhiza glabra'' (licorice). It has estrogenic activity, showing estrogenic effects on breast, vascular, and bone tissue, and hence is a phytoestrogen ( IC50 for estrogen receptor binding = 1&nbs ...
and the isoflavane
glabridin Glabridin is a chemical compound that is found in the root extract of licorice (''Glycyrrhiza glabra''). Glabridin is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols. ...
, found in the roots of liquorice, are
phytoestrogen A phytoestrogen is a plant-derived xenoestrogen (a type of estrogen produced by organisms other than humans) not generated within the endocrine system, but consumed by eating plants or manufactured foods. Also called a "dietary estrogen", it ...
s. The scent of liquorice root comes from a complex and variable combination of compounds, of which
anethole Anethole (also known as anise camphor) is an organic compound that is widely used as a flavoring substance. It is a derivative of the aromatic compound allylbenzene and occurs widely in the essential oils of plants. It is in the class of phenylpr ...
is some 3% of total volatiles. Much of the
sweetness Sweetness is a basic taste most commonly perceived when eating foods rich in sugars. Sweet tastes are generally regarded as pleasurable. In addition to sugars like sucrose, many other chemical compounds are sweet, including aldehydes, ketones ...
in liquorice comes from glycyrrhizin, which has 30–50 times the sweetness of
sugar Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecul ...
. The sweetness is different from sugar, being less instant, tart, and lasting longer.


Cultivation and uses

Liquorice grows best in well-drained soils in deep valleys with full sun. It is harvested in the autumn two to three years after planting. Countries producing liquorice include Turkey, Greece, Iran, and Iraq.


Tobacco

Liquorice is used as a flavouring agent for
tobacco Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
, for flavour-enhancing and moistening agents in the manufacture of American blend
cigarette A cigarette is a narrow cylinder containing a combustible material, typically tobacco, that is rolled into Rolling paper, thin paper for smoking. The cigarette is ignited at one end, causing it to smolder; the resulting smoke is orally inhale ...
s, moist snuff,
chewing tobacco Chewing tobacco is a type of smokeless tobacco, smokeless tobacco product that is placed between the cheek and lower Gums, gum to draw out its flavor. It consists of coarsely chopped aged tobacco that is flavored and often sweetened; it is not gr ...
, and
pipe tobacco A tobacco pipe, often called simply a pipe, is a device specifically made to smoke tobacco. It comprises a chamber (the bowl) for the tobacco from which a thin hollow stem (shank) emerges, ending in a mouthpiece. Pipes can range from very simpl ...
. Liquorice provides tobacco products with a natural sweetness and a distinctive flavour that blends readily with the natural and imitation flavouring components employed in the tobacco industry. Liquorice can also be added to cigarette
rolling paper Rolling paper is a specialty paper used for making cigarettes (commercially manufactured filter cigarettes and individually made roll-your-own cigarettes). Rolling papers are packs of several cigarette-size sheets, often folded inside a cardbo ...
s. , the US
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
banned the use of any "characterizing flavors" other than menthol from cigarettes, but not other manufactured tobacco products.


Food and confectionery

Liquorice flavour is found in a wide variety of candies or sweets. In most of these candies, the taste is reinforced by
aniseed Anise (; '), also called aniseed or rarely anix, is a flowering plant in the family Apiaceae native to the eastern Mediterranean region and Southwest Asia. The flavor and aroma of its seeds have similarities with some other spices and herbs, ...
oil so the actual content of liquorice is low. In the Netherlands, liquorice confectionery (''drop'') is a common sweet sold in many forms. Mixing it with
mint Mint or The Mint may refer to: Plants * Lamiaceae, the mint family ** ''Mentha'', the genus of plants commonly known as "mint" Coins and collectibles * Mint (facility), a facility for manufacturing coins * Mint condition, a state of like-new ...
,
menthol Menthol is an organic compound, specifically a Monoterpene, monoterpenoid, that occurs naturally in the oils of several plants in the Mentha, mint family, such as Mentha arvensis, corn mint and peppermint. It is a white or clear waxy crystallin ...
,
aniseed Anise (; '), also called aniseed or rarely anix, is a flowering plant in the family Apiaceae native to the eastern Mediterranean region and Southwest Asia. The flavor and aroma of its seeds have similarities with some other spices and herbs, ...
, or
laurel Laurel may refer to: Plants * Lauraceae, the laurel family * Laurel (plant), including a list of trees and plants known as laurel People * Laurel (given name), people with the given name * Laurel (surname), people with the surname * Laurel (mus ...
is common. It is also mixed with
ammonium chloride Ammonium chloride is an inorganic chemical compound with the chemical formula , also written as . It is an ammonium salt of hydrogen chloride. It consists of ammonium cations and chloride anions . It is a white crystalline salt (chemistry), sal ...
(); salmiak liquorice in the Netherlands is known as ('
salty liquorice Salty liquorice, also known as salmiak liquorice, salmiac liquorice or (in Finland) , is a variety of liquorice (confectionery), liquorice flavoured with salmiak salt (sal ammoniac; ammonium chloride#Food, ammonium chloride), and is a common co ...
'). Strong, salty sweets are also consumed in
Nordic countries The Nordic countries (also known as the Nordics or ''Norden''; ) are a geographical and cultural region in Northern Europe, as well as the Arctic Ocean, Arctic and Atlantic Ocean, North Atlantic oceans. It includes the sovereign states of Denm ...
where liquorice flavoured alcohols are sold, particularly in Denmark and Finland. Dried sticks of the liquorice root are a traditional confectionery in the Netherlands as were they once in Britain. They were sold simply as sticks of ('sweet wood') to chew on as a candy.
Pontefract Pontefract is a historic market town in the City of Wakefield, a metropolitan district in West Yorkshire, England. It lies to the east of Wakefield and south of Castleford. Historically part of the West Riding of Yorkshire, it is one of the ...
in
Yorkshire Yorkshire ( ) is an area of Northern England which was History of Yorkshire, historically a county. Despite no longer being used for administration, Yorkshire retains a strong regional identity. The county was named after its county town, the ...
, England, is where liquorice mixed with sugar began to be used as a sweet in the contemporary way. Pontefract cakes were originally made there. In Cumbria, County Durham, Yorkshire and Lancashire, it is colloquially known as 'Spanish', supposedly because Spanish monks grew liquorice root at
Rievaulx Abbey Rievaulx Abbey ( ) was a Cistercian abbey in Rievaulx, near Helmsley, in the North York Moors National Park, North Yorkshire, England. It was one of the great abbeys in England until it was seized in 1538 under Henry VIII during the Dissolu ...
near
Thirsk Thirsk is a market town and civil parish in North Yorkshire, England; it is known for its racecourse and depiction as local author James Herriot's fictional Darrowby. History Archeological finds indicate there was a settlement in Thirsk aro ...
. In Italy, Spain, and France, liquorice is used in its natural form. The root of the plant is simply harvested, washed, dried, and chewed as a mouth freshener. Throughout Italy, unsweetened liquorice is consumed in the form of small black pieces made only from 100% pure liquorice extract. In
Calabria Calabria is a Regions of Italy, region in Southern Italy. It is a peninsula bordered by the region Basilicata to the north, the Ionian Sea to the east, the Strait of Messina to the southwest, which separates it from Sicily, and the Tyrrhenian S ...
, a
liqueur A liqueur ( , ; ) is an alcoholic drink composed of Liquor, spirits (often rectified spirit) and additional flavorings such as sugar, fruits, herbs, and spices. Often served with or after dessert, they are typically heavily sweetened and un-age ...
is made from pure liquorice extract and in
Reggio Emilia Reggio nell'Emilia (; ), usually referred to as Reggio Emilia, or simply Reggio by its inhabitants, and known until Unification of Italy, 1861 as Reggio di Lombardia, is a city in northern Italy, in the Emilia-Romagna region. It has about 172,51 ...
a
soft drink A soft drink (see #Terminology, § Terminology for other names) is a class of non-alcoholic drink, usually (but not necessarily) Carbonated water, carbonated, and typically including added Sweetness, sweetener. Flavors used to be Natural flav ...
called acqua d'orcio is made. In some parts of the
Arab world The Arab world ( '), formally the Arab homeland ( '), also known as the Arab nation ( '), the Arabsphere, or the Arab states, comprises a large group of countries, mainly located in West Asia and North Africa. While the majority of people in ...
, including
Egypt Egypt ( , ), officially the Arab Republic of Egypt, is a country spanning the Northeast Africa, northeast corner of Africa and Western Asia, southwest corner of Asia via the Sinai Peninsula. It is bordered by the Mediterranean Sea to northe ...
and the
Levant The Levant ( ) is the subregion that borders the Eastern Mediterranean, Eastern Mediterranean sea to the west, and forms the core of West Asia and the political term, Middle East, ''Middle East''. In its narrowest sense, which is in use toda ...
, the root of the licorice plant is used to make a cold drink with a sweet and mildly bitter taste, called Erk al-sous. This beverage is especially popular during
Ramadan Ramadan is the ninth month of the Islamic calendar. It is observed by Muslims worldwide as a month of fasting (''Fasting in Islam, sawm''), communal prayer (salah), reflection, and community. It is also the month in which the Quran is believed ...
. In southeastern Turkey, such as in
Diyarbakır Diyarbakır is the largest Kurdish-majority city in Turkey. It is the administrative center of Diyarbakır Province. Situated around a high plateau by the banks of the Tigris river on which stands the historic Diyarbakır Fortress, it is ...
, licorice root is traditionally made into a chilled beverage that is most commonly consumed in summer.


Research

Properties of glycyrrhizin are under preliminary research, such as for
hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection period, people often have mild or no symptoms. Early symptoms can include ...
or
topical A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
treatment of
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...
, but the low quality of studies prevents conclusions about efficacy and safety.


Traditional medicine

In
traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medicine, alternative medical practice drawn from traditional medicine in China. A large share of its claims are pseudoscientific, with the majority of treatments having no robust evidence ...
, a related species ''G. uralensis'' (often translated as "liquorice") is known as (), and is believed to "harmonize" the ingredients in a formula. although there is no high-quality
clinical research Clinical research is a branch of medical research that involves people and aims to determine the effectiveness (efficacy) and safety of medications, devices, diagnostic products, and treatment regimens intended for improving human health. The ...
to indicate it is safe or effective for any medicinal purpose. The European Medical Agency added liquorice to their list of herbal medicine.


Fungicide

The
essential oil An essential oil is a concentrated hydrophobic liquid containing volatile (easily evaporated at normal temperatures) chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the ...
s inhibit the growth of ''
Aspergillus flavus ''Aspergillus flavus'' is a saprotrophic and pathogenic fungus with a cosmopolitan distribution. It is best known for its colonization of cereal grains, legumes, and tree nuts. Postharvest rot typically develops during harvest, storage, and/or ...
''.


Adverse effects


Consumption levels

The United States
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
regards that foods containing liquorice and its derivatives (including glycyrrhizin) are
generally recognized as safe Generally recognized as safe (GRAS) is a United States Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts under the conditions of its intended use. An ingredient with a GRAS d ...
for use as a
food ingredient In a general sense, an ingredient is a substance which forms part of a mixture. In cooking, recipes specify which ingredients are used to prepare a dish, and the term may also refer to a specific food item in relation to its use in different re ...
, if not consumed excessively. Other jurisdictions have suggested no more than of glycyrrhizin per day, the equivalent of about of liquorice confectionery. Although liquorice is considered safe as a food ingredient, glycyrrhizin can cause serious side effects if consumed in large amounts (above 0.2 mg per kg per day). One estimate is that a normal healthy person can consume of glycyrrhizic acid per day. Because the composition of liquorice extracts in various products may exist in a broad range, there is not enough scientific information to determine that a specific level of intake is safe or unsafe.


Physiological effects

The effects of excessive liquorice consumption on lowering potassium levels in the blood and increasing
blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...
are a particular concern for people with hypertension (high blood pressure) or heart or kidney disease. Some adverse effects of liquorice consumed in amounts of 50 to 200 g per day over four weeks appear to be caused by
glycyrrhizic acid Glycyrrhizin (glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' (liquorice) root. Structurally, it is a saponin Saponins (Latin ''sapon'', 'soap' + ''-in'', 'one of') are bitter-tasti ...
(75 to 540 mg per day glycyrrhetinic acid) causing increases in blood pressure. Consuming large amounts of liquorice during pregnancy has been associated with
premature birth Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is betwee ...
and health problems in the child. Hyper- mineralocorticosteroid syndrome can occur when the body retains sodium, and loses potassium, altering biochemical and hormonal regulation. Some of these activities may include raised
aldosterone Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays ...
levels, decline of the renin-angiotensin system and increased levels of the
atrial natriuretic hormone Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the ''NPPA'' gene. Natriuretic peptides (ANP, BNP, and CNP) are a family of ho ...
in order to compensate the variations in homoeostasis. Other adverse effects may include
electrolyte imbalance Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body. Electrolytes play a vital role in maintaining homeostasis in the body. They help to regulate heart and neurological function ...
,
edema Edema (American English), also spelled oedema (British English), and also known as fluid retention, swelling, dropsy and hydropsy, is the build-up of fluid in the body's tissue (biology), tissue. Most commonly, the legs or arms are affected. S ...
, increased
blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...
, weight gain, heart problems, and weakness. Symptoms depend on the severity of toxicity. Some other complaints include fatigue,
shortness of breath Shortness of breath (SOB), known as dyspnea (in AmE) or dyspnoea (in BrE), is an uncomfortable feeling of not being able to breathe well enough. The American Thoracic Society defines it as "a subjective experience of breathing discomfort that con ...
,
kidney failure Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney fa ...
, and paralysis.


Potential for toxicity

The major dose-limiting toxicities of liquorice are
corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...
in nature, because of the inhibitory effect that its chief active constituents, glycyrrhizin and enoxolone, have on
cortisol Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. When used as medication, it is known as hydrocortisone. Cortisol is produced in many animals, mainly by the ''zona fasciculata'' of the adrenal corte ...
degradation, and include
edema Edema (American English), also spelled oedema (British English), and also known as fluid retention, swelling, dropsy and hydropsy, is the build-up of fluid in the body's tissue (biology), tissue. Most commonly, the legs or arms are affected. S ...
,
hypokalaemia Hypokalemia is a low level of potassium (K+) in the blood serum. Mild low potassium does not typically cause symptoms. Symptoms may include feeling tired, leg cramps, weakness, and constipation. Low potassium also increases the risk of an ...
, weight gain or loss, and
hypertension Hypertension, also known as high blood pressure, is a Chronic condition, long-term Disease, medical condition in which the blood pressure in the artery, arteries is persistently elevated. High blood pressure usually does not cause symptoms i ...
.


Gallery

File:Réglisse(racine).JPG, Liquorice root with bark File:Glycyrrhiza glabra inflorescence.jpg, Inflorescence of ''G. glabra'' File:2013.02-402-022aP Liquorice products tue05feb2013.jpg, Various liquorice products File:Liquorice4.jpg, Different flavoured liquorice sticks File:Gardenology.org-IMG 2804 rbgs11jan.jpg, Foliage File:Glycyrrhiza glabra - Köhler–s Medizinal-Pflanzen-207.jpg, ''G. glabra'' from Koehler's ''Medicinal-Plants''


References


External links

*
''Glycyrrhiza glabra'' (licorice)
Kew plant profile

''
Chemical & Engineering News ''Chemical & Engineering News'' (''C&EN'') is a weekly news magazine published by the American Chemical Society (ACS), providing professional and technical news and analysis in the fields of chemistry and chemical engineering. 11β-Hydroxysteroid dehydrogenase inhibitors Glycyrrhiza Spices Medicinal plants Plants used in traditional Chinese medicine Monoamine oxidase inhibitors Demulcents Plants described in 1753 Indian spices