Laurence Daniel Hurst (born 6 January 1965) is a Professor of

Evolution Evolution is the change in the heritable Phenotypic trait, characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, re ...

ary

Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

in the Department of

Biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...

and

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

at the

University of Bath The University of Bath is a public research university in Bath, England. Bath received its royal charter in 1966 as Bath University of Technology, along with a number of other institutions following the Robbins Report. Like the University ...

and the director of th
Milner Centre for Evolution
until April, 202

ref name=zoo> Zoological Society of London Scientific Medal Winnershttp://www.genetics.org.uk/page/2775/2010-Genetics-Society-Medal.html 2010 Genetics Society Medal

Education

Hurst was educated at

Truro School Truro School is a coeducational private boarding and day school located in the city of Truro, Cornwall, England. It is the largest coeducational independent school in Cornwall with over 1050 pupils from pre-prep to sixth form. It is a member s ...

and the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

where he studied the

Natural Sciences Tripos The Natural Sciences Tripos is the framework within which most of the science at the University of Cambridge is taught. The tripos includes a wide range of Natural Sciences from physics, astronomy, and geoscience, to chemistry and biology, whi ...

Churchill College, Cambridge Churchill College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge in Cambridge, England. It has a primary focus on science, engineering and technology, but retains a strong interest in the arts ...

, graduating with a

Bachelor of Arts A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts deg ...

degree in 1987. After a year at

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

he returned to the UK, and was awarded a

Doctor of Philosophy A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original resear ...

(DPhil) degree from the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

in 1991 for research supervised by

W. D. Hamilton William Donald Hamilton (1 August 1936 – 7 March 2000) was a British evolutionary biologist, recognised as one of the most significant evolutionary theorists of the 20th century. Hamilton became known for his theoretical work expounding a ...

and Alan Grafen.

Career and Research

Hurst was a

Royal Society University Research Fellow __NOTOC__ The Royal Society University Research Fellowship (URF) is a research fellowship awarded to outstanding early career scientists in the United Kingdom who are judged by the Royal Society The Royal Society, formally The Royal Society ...

at the

from 1993 to 1996 and has been a professor at the University of Bath since 1997. His research interests include evolution, genetics and genomics using

computational A computation is any type of arithmetic or non-arithmetic calculation that is well-defined. Common examples of computation are mathematical equation solving and the execution of computer algorithms. Mechanical or electronic devices (or, historic ...

and mathematical techniques to understand the way genes and genomes evolve. This has resulted in work on housekeeping genes, gene orders, and the evolution of

drug resistance Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. The term is used in the context of resistance that pathogens or cancers have "acquired", that is ...

in ''

Staphylococcus aureus ''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often posi ...

'', ''

Saccharomyces cerevisiae ''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungal microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have be ...

'' and the

evolution of sexual reproduction Sexually reproducing animals, plants, fungi and protists are thought to have evolved from a common ancestor that was a single-celled eukaryotic species. Sexual reproduction is widespread in eukaryotes, though a few eukaryotic species have ...

sexual dimorphism Sexual dimorphism is the condition where sexes of the same species exhibit different Morphology (biology), morphological characteristics, including characteristics not directly involved in reproduction. The condition occurs in most dioecy, di ...

. Hurst works on fundamental problems in the evolution of genetic systems, such as understanding why some sorts of mutations are less damaging than predicted whilst others are more damaging. Mutations that change proteins are, surprisingly, often not especially deleterious. Hurst showed that this was because the

genetic code Genetic code is a set of rules used by living cell (biology), cells to Translation (biology), translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets or codons) into proteins. Translation is accomplished ...

is structured in a way that renders it highly error-proof. Similarly, in applying network representations of gene interactions, he revealed why many deletions of genes have little effect and which deletions tend not to be

recessive In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and ...

. One or more of the preceding sentences incorporates text from the royalsociety.org website where: By contrast, Hurst revealed that genomic changes often considered to be relatively harmless – such as gene order changes and mutations at 'silent' sites – are under selection for unanticipated reasons. He also showed how synonymous mutations can disrupt the way gene transcripts are processed. Similarly, in showing that genomes are arranged into gene expression domains, Hurst revealed that genes can affect the expression of other genes in their vicinity. translation of this fundamental work to medicine is a focus of his research.

Awards and honours

Hurst was elected a Fellow of the Academy of Medical Sciences (FMedSci) and a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

(FRS) in 2015. His certificate of election to the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

reads: Hurst was awarded the Scientific Medal of the

Zoological Society of London The Zoological Society of London (ZSL) is a charity and organization devoted to the worldwide animal conservation, conservation of animals and their habitat conservation, habitats. It was founded in 1826. Since 1828, it has maintained London Zo ...

in 2003, and elected a member of

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

(EMBO) in 2004. He was awarded

The Genetics Society The Genetics Society is a British learned society. It was founded by William Bateson and Edith Rebecca Saunders in 1919 and celebrated its centenary year in 2019. It is therefore one of the oldest learned societies devoted to genetics. Its membe ...

Medal in 2010.

References

{{DEFAULTSORT:Hurst, Laurence Living people People educated at Truro School Members of the European Molecular Biology Organization British bioinformaticians Academics of the University of Bath Alumni of the University of Oxford Alumni of Churchill College, Cambridge Fellows of the Royal Society 1965 births People from Ilkley