Kurzrock–Miller Test
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The Kurzrock–Miller test is an
in-vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') studies are performed with cells or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology and its subdis ...
test of sperm–mucus interaction. It consists of establishing an interface between
cervical mucus The cervix (: cervices) or cervix uteri is a dynamic fibromuscular sexual organ of the female reproductive system that connects the vagina with the uterine cavity. The human female cervix has been documented anatomically since at least the tim ...
and liquefied
semen Semen, also known as seminal fluid, is a bodily fluid that contains spermatozoon, spermatozoa which is secreted by the male gonads (sexual glands) and other sexual organs of male or hermaphrodite, hermaphroditic animals. In humans and placen ...
. It is one of the tests used for investigating
infertility In biology, infertility is the inability of a male and female organism to Sexual reproduction, reproduce. It is usually not the natural state of a healthy organism that has reached sexual maturity, so children who have not undergone puberty, whi ...
.


Etymology

The test is named after Raphael Kurzrock and Thomas Grier Miller.


Interpretation

# Negative test: Spermatozoa congregate on semen side of the interface, but do not penetrate it. # Abnormal: Spermatozoa penetrate the mucus, but rapidly become immobile or acquire shaking movement. # Poor: after penetration, spermatozoa do not progress farther than 500 μm. # Normal: Spermatozoa penetrate the mucus and >90% are motile with definite progression, crossing 3 cm at 30 minutes.Padubidri; Daftary (2011). ''Shaw's Textbook of Gynaecology, 15e.'' p. 204.


See also

*
Hamster egg penetration test The hamster zona-free ovum test (HZFO test), or hamster egg-penetration test, or sometimes just hamster test, is an in-vitro test used to study physiological profile of spermatozoa. The primary application of the test is to diagnose male infertili ...
*
Postcoital test The postcoital test (PCT), also known as the Sims test, Hühner test ,Sims–Hühner test, or cervical mucous penetration assay is a test in the evaluation of infertility. The test examines interaction between sperm and mucus of the cervix. The P ...
*
Sperm–cervical mucus contact test The sperm–cervical mucus contact test is an in-vitro slide test used for detecting antispermal antibodies. It is one of the investigations done for infertility. It should not be confused with Kurzrock–Miller test, where there is interface betw ...


References

{{DEFAULTSORT:Kurzrock-Miller test Fertility medicine Medical tests