Kendomycin is an anticancer
macrolide
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. M ...
first isolated from ''
Streptomyces violaceoruber
''Streptomyces violaceoruber'' is a bacterium species from the genus of ''Streptomyces''.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces violaceoruber'' produces protoactinorhodin, kendomycin, phospholipase A2, g ...
''.
It has potent activity as an
endothelin receptor
There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels ...
antagonist and anti-
osteoporosis agent.
It also has strong cytotoxicity against various tumor cell lines.
Total synthesis
Because of its potent biological activities, kendomycin has attracted interest as a target of
total synthesis
Total synthesis is the complete chemical synthesis of a complex molecule, often a natural product, from simple, commercially-available precursors. It usually refers to a process not involving the aid of biological processes, which distinguishes i ...
. The first total synthesis of kendomycin was accomplished by Lee and Yuan in 2004. The total number of syntheses stands at 6.
References
{{reflist
Macrolides
Antibiotics
Quinone methides
Total synthesis