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Streptomyces Violaceoruber
''Streptomyces violaceoruber'' is a bacterium species from the genus of ''Streptomyces''.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces violaceoruber'' produces protoactinorhodin, kendomycin, phospholipase A2 The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycero ..., granaticin and methylenomycin A. Further reading * * * * * * * * See also * List of Streptomyces species References violaceoruber Bacteria described in 1970 {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces
''Streptomyces'', from στρεπτός (''streptós''), meaning "twisted", and μύκης (''múkés''), meaning "fungus", is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Different strains of the same species may colonize very diverse environments. Streptomycetes are characterised by a complex secondary metabolism. Between 5-23% (average: 12%) of the protein-coding genes of each ''Streptomyces'' species are implicated in secondary metabolism. Streptomycetes produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deutsche Sammlung Von Mikroorganismen Und Zellkulturen
The Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH (German: ''Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH''), located in Braunschweig, is a research infrastructure in the Leibniz Association. Originally a culture collection for microbes (DSM), the DSMZ has expanded to provide cell cultures, online bioinformatic services, and offline analysis services. It also hosts research projects. As of 2021, DSMZ is the world's most diverse collection of bioresources with 75,000 different accessions. These include microorganisms (including more than 32,000 bacterial strains, 690 archaeal strains, 7,000 strains of yeasts and fungi) as well as more than 840 human and animal cell cultures, over 1,500 plant viruses, over 940 bacteriophages, and 250 plasmids (status 2021). Since 2010, the scientific director of the Leibniz Institute DSMZ has been Jörg Overmann, a microbiologist with a PhD from the University of Konstanz. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kendomycin
Kendomycin is an anticancer macrolide first isolated from ''Streptomyces violaceoruber''. It has potent activity as an endothelin receptor antagonist and anti-osteoporosis agent. It also has strong cytotoxicity against various tumor cell lines. Total synthesis Because of its potent biological activities, kendomycin has attracted interest as a target of total synthesis Total synthesis, a specialized area within organic chemistry, focuses on constructing complex organic compounds, especially those found in nature, using laboratory methods. It often involves synthesizing natural products from basic, commercially .... The first total synthesis of kendomycin was accomplished by Lee and Yuan in 2004. The total number of syntheses stands at 6. References {{reflist Macrolides Antibiotics Quinone methides Total synthesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipase A2
The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule: :phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate This particular phospholipase specifically recognizes the ''sn''2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidyl choline, a precursor of lysophosphatidic acid. Upon downstream modification by cyclooxygenases or lipoxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators. PLA2 enzymes are commonly found in mammalian tissues as well as arachnid, insect, and snake venom. Venom from bees is largely composed of melittin, which is a stimulan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methylenomycin A
Methylenomycin A is a cyclopentanone derived antibiotic produced by ''Streptomyces coelicolor'' A3(2) that is effective against both Gram-negative and Gram-positive In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. The Gram stain is ... bacteria. Methylenomycins are naturally produced in two variants: A and B. See also * Methylenomycin B References Antibiotics Epoxides Enones Carboxylic acids Oxygen heterocycles Vinylidene compounds {{Antibiotic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Streptomyces Species
The following is a list of ''Streptomyces'' species, organized alphabetically by species name. Names that have not been validated according to the Bacteriological Code are enclosed in "quotes". , there are 679 valid species of ''Streptomyces'' and an additional 121 provisional species. New species continue to be discovered (''e.g.'', '' S. gossypiisoli'', described in 2021). Many species are named after their colorful hyphae and/or spores. A * '' Streptomyces abietis'' Fujii ''et al''. 2013 * '' Streptomyces abikoensis'' (Umezawa ''et al''. 1951) Witt and Stackebrandt 1991 * '' Streptomyces abyssalis'' Xu ''et al''. 2012 * "'' Streptomyces abyssomicinicus''" Komaki ''et al''. 2020 * '' Streptomyces achromogenes'' Okami and Umezawa 1953 (Approved Lists 1980) * '' Streptomyces acidicola'' Lipun ''et al''. 2020 * ''Streptomyces acidiscabies'' Lambert and Loria 1989 * '' Streptomyces actinomycinicus'' Tanasupawat ''et al''. 2016 * "'' Streptomyces actuosus''" Pinnert ''et al''. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
