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Joseph Erlanger (January 5, 1874 – December 5, 1965) was an American
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...
who is best known for his contributions to the field of
neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...
. Together with Herbert Spencer Gasser, he identified several varieties of
nerve fiber An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see spelling differences) is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action pot ...
and established the relationship between
action potential An action potential (also known as a nerve impulse or "spike" when in a neuron) is a series of quick changes in voltage across a cell membrane. An action potential occurs when the membrane potential of a specific Cell (biology), cell rapidly ri ...
velocity and fiber diameter. They were awarded the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
in 1944 for these achievements.


Biography

Erlanger was born on January 5, 1874, in
San Francisco San Francisco, officially the City and County of San Francisco, is a commercial, Financial District, San Francisco, financial, and Culture of San Francisco, cultural center of Northern California. With a population of 827,526 residents as of ...
,
California California () is a U.S. state, state in the Western United States that lies on the West Coast of the United States, Pacific Coast. It borders Oregon to the north, Nevada and Arizona to the east, and shares Mexico–United States border, an ...
. His family was Jewish and his parents both immigrated from the
Kingdom of Württemberg The Kingdom of Württemberg ( ) was a German state that existed from 1806 to 1918, located within the area that is now Baden-Württemberg. The kingdom was a continuation of the Electorate of Württemberg, which existed from 1803 to 1806. Geogr ...
,
Germany Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...
and met in California during the
Gold Rush A gold rush or gold fever is a discovery of gold—sometimes accompanied by other precious metals and rare-earth minerals—that brings an onrush of miners seeking their fortune. Major gold rushes took place in the 19th century in Australia, ...
. Joseph was the sixth of seven children born to the couple. He completed his
Bachelor of Science A Bachelor of Science (BS, BSc, B.S., B.Sc., SB, or ScB; from the Latin ') is a bachelor's degree that is awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Scienc ...
in Chemistry from the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...
in 1895. He then completed his M.D. in 1899 from the
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Established in 1893 following the construction of the Johns Hopkins Hospital, th ...
in
Baltimore Baltimore is the most populous city in the U.S. state of Maryland. With a population of 585,708 at the 2020 census and estimated at 568,271 in 2024, it is the 30th-most populous U.S. city. The Baltimore metropolitan area is the 20th-large ...
,
Maryland Maryland ( ) is a U.S. state, state in the Mid-Atlantic (United States), Mid-Atlantic region of the United States. It borders the states of Virginia to its south, West Virginia to its west, Pennsylvania to its north, and Delaware to its east ...
, where he finished second in his class. Upon graduating, Erlanger interned at Johns Hopkins Hospital under
William Osler Sir William Osler, 1st Baronet, (; July 12, 1849 – December 29, 1919) was a Canadian physician and one of the "Big Four" founding professors of Johns Hopkins Hospital. Osler created the first Residency (medicine), residency program for speci ...
and worked in a physiology laboratory. Erlanger also gave lectures at the school on digestion and metabolism. Erlanger also had an interest in
cardiology Cardiology () is the study of the heart. Cardiology is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery di ...
, specifically the way that excitation transferred from the atrium to the ventricle and researched with Arthur Hirschfelder. Erlanger developed and patented a new type of
sphygmomanometer A sphygmomanometer ( ), also known as a blood pressure monitor, blood pressure machine, or blood pressure gauge, is a device used to measure blood pressure, composed of an inflatable cuff to collapse and then release the artery under the cuff i ...
that could measure
blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...
from the
brachial artery The brachial artery is the major blood vessel of the (upper) arm. It is the continuation of the axillary artery beyond the lower margin of teres major muscle. It continues down the ventral surface of the arm until it reaches the cubital fossa ...
. While working at
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Established in 1893 following the construction of the Johns Hopkins Hospital, th ...
in 1901, Erlanger published a paper on the digestive systems of canines. This paper caught the attention of William Henry Howell, a
physiology Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...
professor at
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Established in 1893 following the construction of the Johns Hopkins Hospital, th ...
. Howell recruited Erlanger as an assistant professor. Erlanger was promoted to associate professor some time before 1906. In 1906, Erlanger accepted a position as the first chair of physiology at the
University of Wisconsin A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Uni ...
in Madison. In 1910, he left to take a position as professor at Washington University in St. Louis; the St. Louis position offered Erlanger more funding for his projects. Herbert Spencer Gasser, Erlanger's former student at Wisconsin, joined Erlanger's laboratory soon after the move. During
World War I World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to ...
, the pair contributed to the research effort examining the effects of shock. As part of this work, Erlanger was able to produce heart block in an animal model by clamping the
bundle of His The bundle of His (BH) or His bundle (HB) ( "hiss"Medical Terminology for Health Professions, Spiral bound Version'. Cengage Learning; 2016. . pp. 129–.) is a collection of heart muscle cells specialized for electrical conduction. As part of ...
and tightening it. Together, they managed to amplify the action potential of a bullfrog
sciatic nerve The sciatic nerve, also called the ischiadic nerve, is a large nerve in humans and other vertebrate animals. It is the largest branch of the sacral plexus and runs alongside the hip joint and down the right lower limb. It is the longest and widest ...
in 1922 and published the results in the ''
American Journal of Physiology The ''American Journal of Physiology'' is a peer-reviewed scientific journal on physiology published by the American Physiological Society. Vols. for 1898–1941 and 1948-56 include the Society's proceedings, including abstracts of papers present ...
''. It is uncertain why the pair had such a sudden shift in interest to
neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...
, as Erlanger was already widely respected in the cardiology field. Erlanger was elected to the United States
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
in 1922 and the
American Philosophical Society The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...
in 1927. Erlanger and Gasser were able to modify a
Western Electric Western Electric Co., Inc. was an American electrical engineering and manufacturing company that operated from 1869 to 1996. A subsidiary of the AT&T Corporation for most of its lifespan, Western Electric was the primary manufacturer, supplier, ...
oscilloscope An oscilloscope (formerly known as an oscillograph, informally scope or O-scope) is a type of electronic test instrument that graphically displays varying voltages of one or more signals as a function of time. Their main purpose is capturing i ...
to run at low voltages. Prior to this modification, the only method available to measure neural activity was the electroencephalograph, which could only show large-scale electrical activity. With this technology, they were able to observe that action potentials occurred in two phases—a spike (initial surge) followed by an after-spike (a sequence of slow changes in potential). They discovered that
neuron A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...
s were found in many forms, each with their own potential for excitability. With this research, the pair discovered that the velocity of action potentials was directly proportional to the diameter of the nerve fiber. The partnership ended in 1931, when Gasser accepted a position at
Cornell University Cornell University is a Private university, private Ivy League research university based in Ithaca, New York, United States. The university was co-founded by American philanthropist Ezra Cornell and historian and educator Andrew Dickson W ...
. In 1944, they won the
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
in Medicine or Physiology for these discoveries. He died of heart disease on December 5, 1965, at St. Louis,
Missouri Missouri (''see #Etymology and pronunciation, pronunciation'') is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it border ...
. The Joseph Erlanger House in St. Louis was designated a
National Historic Landmark A National Historic Landmark (NHL) is a National Register of Historic Places property types, building, district, object, site, or structure that is officially recognized by the Federal government of the United States, United States government f ...
on December 8, 1976, as a building of national significance. On January 22, 2009, the
International Astronomical Union The International Astronomical Union (IAU; , UAI) is an international non-governmental organization (INGO) with the objective of advancing astronomy in all aspects, including promoting astronomical research, outreach, education, and developmen ...
named a crater on the
Moon The Moon is Earth's only natural satellite. It Orbit of the Moon, orbits around Earth at Lunar distance, an average distance of (; about 30 times Earth diameter, Earth's diameter). The Moon rotation, rotates, with a rotation period (lunar ...
after him.


Citations


See also

* List of Jewish Nobel laureates


References

* *


External links

* including the Nobel Lecture on December 12, 1946 ''The Discovery of Vitamin K, Its Biological Functions and Therapeutical Application'' *
National Academy of Sciences Biographical Memoir
{{DEFAULTSORT:Erlanger, Joseph 1874 births 1965 deaths Nobel laureates in Physiology or Medicine American Nobel laureates American people of German-Jewish descent American physiologists American neuroscientists Jewish American scientists Jewish Nobel laureates Johns Hopkins School of Medicine alumni Lowell High School (San Francisco) alumni Scientists from San Francisco Scientists from St. Louis University of California, Berkeley alumni Washington University School of Medicine faculty Johns Hopkins School of Medicine faculty Members of the American Philosophical Society