Josef Kyrle (8 December 1880 – 30 March 1926) was an Austrian

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and

dermatologist Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medi ...

who was a native of

Schärding Schärding ( , Bavarian name: Scharing) is a town in the northern Austrian state of Upper Austria, the capital of the district of the same name, and a major port on the Inn River. Historically, it was owned by the Wittelsbach family, which is r ...

. He studied medicine at the

University of Graz The University of Graz (, formerly: ''Karl-Franzens-Universität Graz'') is a public university, public research university located in Graz, Austria. It is the largest and oldest university in Styria, as well as the second-largest and second-old ...

, and afterwards was an assistant to Anton Weichselbaum (1845–1920) at the clinic of

pathological anatomy Anatomical pathology (''Commonwealth'') or anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the gross examination, macroscopic, Histopathology, microscopic, biochemical, immu ...

at the

University of Vienna The University of Vienna (, ) is a public university, public research university in Vienna, Austria. Founded by Rudolf IV, Duke of Austria, Duke Rudolph IV in 1365, it is the oldest university in the German-speaking world and among the largest ...

. In 1907 he was an assistant to

Ernst Finger Ernst Anton Franz Finger (name also spelled Ernest; 8 July 1856 – 17 April 1939) was an Austrian dermatologist born in Prague. He was a leading authority regarding venereal disease. In 1878 he obtained his medical doctorate at the University of ...

(1856–1939) at the dermatology clinic in

Vienna Vienna ( ; ; ) is the capital city, capital, List of largest cities in Austria, most populous city, and one of Federal states of Austria, nine federal states of Austria. It is Austria's primate city, with just over two million inhabitants. ...

, and in 1918 he became an associate professor. Kyrle specialized in microscopic and

histological Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at large ...

research of skin disorders. His name is associated with

Kyrle disease Kyrle disease is identified as a form of an acquired perforating disease. Other major perforating diseases are elastosis perforans serpiginosa and reactive perforating collagenosis. Recently, however, there is a controversy on categorizing Kyrle ...

, being also known as "

hyperkeratosis Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin), often associated with the presence of an abnormal quantity of keratin,Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) ''Robbins & Cotran Pathol ...

penetrans". In 1916 Kyrle referred to this condition as ''hyperkeratosis follicularis et parafollicularis in cutem penetrans''. It is characterized by keratotic plugs that develop in

hair follicle The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction betwee ...

s and eccrine ducts, penetrating the

epidermis The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and Subcutaneous tissue, hypodermis. The epidermal layer provides a barrier to infection from environmental pathogens and regulates the ...

and extending into the

dermis The dermis or corium is a layer of skin between the epidermis (skin), epidermis (with which it makes up the cutis (anatomy), cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from s ...

. This disorder is often associated with

diabetes mellitus Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained hyperglycemia, high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or th ...

and

kidney failure Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney fa ...

. He performed investigations on the use of Jauregg's

malaria Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomitin ...

therapy for treatment of

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...

in its early stages, and with Dr. Weichselbaum, he performed important studies involving the origin and development of the

islets of Langerhans The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1–2% o ...

in the fetus.

Selected writings

* ''Über den derzeitigen Stand der Lehre von der Pathologie und Therapie der Syphilis; sechs Vorlesungen für praktische Ärzte'', 1924 - On the current state involving the doctrine of pathology and therapy of syphilis. * ''Vorlesungen über Histo-Biologie der menschlichen Haut und ihrer Erkrankungen'', 1925-27 - Lectures about histo-biology of

human skin The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue (biology), tissue guarding Skeletal muscle, muscles, bones, ligaments and organ (anato ...

and its diseases.WorldCat Search
(publications)

References

Kyrle's disease *

(translated from German) * ttp://nobelprize.org/nobel_prizes/medicine/laureates/1927/wagner-jauregg-lecture.htmlThe Treatment of Dementia Paralytica by Malaria Inoculation Austrian dermatologists Austrian pathologists 1880 births 1926 deaths Academic staff of the University of Vienna Dermatologists from Austria-Hungary Pathologists from Austria-Hungary {{austria-med-bio-stub