John Farrar Soothill (20 August 1925 – 23 September 2004) was an English medical doctor. He began his career as a

nephrologist Nephrology is a specialty for both adult internal medicine and pediatric medicine that concerns the study of the kidneys, specifically normal kidney function (renal physiology) and kidney disease (renal pathophysiology), the preservation of kid ...

and later became a

paediatric Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Prev ...

immunologist at

Great Ormond Street Hospital Great Ormond Street Hospital (informally GOSH, formerly the Hospital for Sick Children) is a children's hospital located in the Bloomsbury area of the London Borough of Camden, and a part of Great Ormond Street Hospital for Children NHS F ...

Biography

John Soothill was born in 1925 in

Blackheath, London Blackheath is an area in Southeast London, straddling the border of the Royal Borough of Greenwich and the London Borough of Lewisham. Historically within the county of Kent, it is located northeast of Lewisham, south of Greenwich, London, G ...

. His father was the chief medical officer in

Norwich Norwich () is a cathedral city and district of the county of Norfolk, England, of which it is the county town. It lies by the River Wensum, about north-east of London, north of Ipswich and east of Peterborough. The population of the Norwich ...

and his grandfather,

William Edward Soothill William Edward Soothill, (1861 – 1935) was a Methodist missionary to China who later became Shaw Professor of Chinese, Professor of Chinese at the University of Oxford, and a leading British sinologist. Life Born in Halifax, West Yorkshire ...

, had been the first professor of

sinology Sinology, also referred to as China studies, is a subfield of area studies or East Asian studies involved in social sciences and humanities research on China. It is an academic discipline that focuses on the study of the Chinese civilization p ...

Oxford University The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the second-oldest continuously operating u ...

. He attended

The Leys School The Leys School is a co-educational private school in Cambridge, England. It is a boarding and day school for about 565 pupils between the ages of eleven and eighteen. The head is a member of the Headmasters' and Headmistresses' Conference. ...

, Cambridge, and in spite of his

dyslexia Dyslexia (), previously known as word blindness, is a learning disability that affects either reading or writing. Different people are affected to different degrees. Problems may include difficulties in spelling words, reading quickly, wri ...

went on to study medicine at

Christ's College, Cambridge Christ's College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge, England. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 250 graduate students. The c ...

. He completed his national service in Germany, did his clinical training at

Guy's Hospital Guy's Hospital is an NHS hospital founded by philanthropist Thomas Guy in 1721, located in the borough of Southwark in central London. It is part of Guy's and St Thomas' NHS Foundation Trust and one of the institutions that comprise the Kin ...

and

Lewisham Hospital University Hospital Lewisham (formerly known as Lewisham Hospital) is a teaching hospital run by Lewisham and Greenwich NHS Trust and serving the London Borough of Lewisham. It is now affiliated with King's College London and forms part of the Ki ...

. In 1955 he travelled to Chicago on a

Fulbright Scholarship The Fulbright Program, including the Fulbright–Hays Program, is one of several United States cultural exchange programs with the goal of improving intercultural relations, cultural diplomacy, and intercultural competence between the people ...

, where he studied the recently developed technique of

renal biopsy Renal biopsy (also kidney biopsy) is a medical procedure in which a small piece of kidney is removed from the body for examination, usually under a microscope. Microscopic examination of the tissue can provide information needed to diagnose, moni ...

. Soothill began working at

Birmingham University The University of Birmingham (informally Birmingham University) is a Public university, public research university in Birmingham, England. It received its royal charter in 1900 as a successor to Queen's College, Birmingham (founded in 1825 as ...

's experimental pathology department in 1956 as a

. His work at Birmingham centred around

kidney disease Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an Inflammation, inflammatory kidney disease and has several types according to the location of the inflammation. Infla ...

immunoglobin An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that cause di ...

s and the

complement system The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inf ...

. He also pioneered the use of

cyclophosphamide Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer ...

in children with relapsing

nephrotic syndrome Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes proteinuria, protein in the urine, hypoalbuminemia, low blood albumin levels, hyperlipidemia, high blood lipids, and significant edema, swelling. Other symptoms ...

. In 1965, Soothill moved from Birmingham to the

UCL Great Ormond Street Institute of Child Health The UCL Great Ormond Street Institute of Child Health (ICH) is an academic department of the Faculty of Population Health Sciences of University College London (UCL) and is located in London, United Kingdom. It was founded in 1946 and together ...

, where he was appointed the first Hugh Greenwood Professor of Immunology, a post he would hold for 20 years. One of his main achievements at Great Ormond Street was classifying the different subtypes of

severe combined immunodeficiency Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in diff ...

(SCID). The disease, informally known as "boy in the bubble syndrome" after

David Vetter David Phillip Vetter (September 21, 1971 – February 22, 1984) was an American boy with severe combined immunodeficiency (SCID), a hereditary disease that dramatically weakens the immune system. Individuals born with SCID are abnormally su ...

, was given its current name by Soothill in the 1970s. He also focused on childhood allergies, proposing the theory that allergies and

eczema Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened ...

resulted from the exposure to allergens in the first six months of a baby's life. He pioneered the use of

elimination diet An elimination diet, also known as exclusion diet, is a diagnostic procedure used to identify foods that an individual cannot consume without adverse effects. Adverse effects may be due to food allergy, food intolerance, other physiological mechan ...

s whereby a child with an unknown

food allergy A food allergy is an abnormal immune system, immune response to food. The symptoms of the allergic reaction may range from mild to severe. They may include pruritus, itchiness, swelling of the tongue, vomiting, diarrhea, hives, trouble breathi ...

is denied all possible allergic sources in their diet, then each food is reintroduced one by one until the causative food is identified. Soothill retired in 1985 to

Devon Devon ( ; historically also known as Devonshire , ) is a ceremonial county in South West England. It is bordered by the Bristol Channel to the north, Somerset and Dorset to the east, the English Channel to the south, and Cornwall to the west ...

with his wife Brenda Thornton, whom he had married in 1951. He died on 23 September 2004 in

Axminster Axminster is a market town and civil parishes in England, civil parish on the eastern border of the county of Devon in England. It is from the county town of Exeter. The town is built on a hill overlooking the River Axe, Devon, River Axe which ...

References

{{DEFAULTSORT:Soothill, John 1925 births 2004 deaths British immunologists British nephrologists British paediatricians People educated at The Leys School Alumni of Christ's College, Cambridge Medical doctors from Norwich Physicians of Guy's Hospital Physicians of Great Ormond Street Hospital