John Charles Cutler
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John Charles Cutler (June 29, 1915 – February 8, 2003) was an American surgeon. He was the acting chief of the
venereal disease A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, or ...
program in the
United States Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services which manages public health, containing nine out of the department's twelve operating divisions. The assistant s ...
. He is known for leading several controversial and unethical human experiments of
syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...
, done under the auspices of the Public Health Service. He willfully spread syphilis and gonorrhea to unwitting patients including (but not limited to) soldiers, prisoners, adults with leprosy, mental patients and orphan children as young as nine in the Guatemala syphilis experiments. He also conducted the
Tuskegee syphilis experiment The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Cent ...
s, in which African American men, not informed of the nature of the experiment, were deliberately denied treatment for syphilis.


Early life and education

Cutler was born on June 29, 1915, in
Cleveland Cleveland is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located along the southern shore of Lake Erie, it is situated across the Canada–U.S. maritime border and approximately west of the Ohio-Pennsylvania st ...
, Ohio, to Grace Amanda Allen and Glenn Allen Cutler. He graduated from Western Reserve University Medical School in 1941, and joined the
Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services which manages public health, containing nine out of the department's twelve operating divisions. The Assistant Se ...
in 1942. In 1943 he worked as a medical officer in the U.S. Public Health Venereal Disease Research Laboratory on
Staten Island Staten Island ( ) is the southernmost of the boroughs of New York City, five boroughs of New York City, coextensive with Richmond County and situated at the southernmost point of New York (state), New York. The borough is separated from the ad ...
.


Syphilis experiments

Cutler, together with John Friend Mahoney, oversaw the Terre Haute prison experiments in 1943 and 1944, in which inmates at a federal penitentiary agreed to be injected with strains of
gonorrhea Gonorrhoea or gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium ''Neisseria gonorrhoeae''. Infection may involve the genitals, mouth, or rectum. Gonorrhea is spread through sexual c ...
in return for $100, a certificate of merit, and a letter of commendation to the parole board. The experiments were discontinued when Cutler's supervisor determined that the method of inducing gonorrhea in humans was unreliable and could not provide meaningful tests of prophylactic agents. Cutler, supervised by Mahoney, then resumed these experiments, conducted by the United States Public Health Service with funding from the United States
National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
(NIH), as part of the syphilis experiments in Guatemala beginning in 1946, during which American and Guatemalan doctors deliberately infected an estimated 1500 to 5000 Guatemalans with syphilis without the informed consent of the subjects. Unwitting subjects of the experiments included orphans as young as nine,Rory Carroll
Guatemala victims of US syphilis study still haunted by the “devil’s experiment”
''
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardi ...
'', 8 June 2011.
as well as soldiers, prisoners and mental patients. In one especially "offensive" case from the Guatemala experiments, a mental patient named Bertha was first deliberately infected with syphilis and given penicillin only months later. Cutler, after observing that she "appeared she was going to die", inserted pus from a male gonorrhea victim into her eyes, urethra and rectum. Four days later, infected in both eyes and bleeding from the urethra, she died. In another case, several epileptic women in Guatemala were injected with syphilis below the base of their skull. One was left paralyzed for two months by meningitis. Cutler said he was testing a theory that the injections could cure epilepsy. Approximately half of those infected as part of the study were treated for the diseases they contracted. A total of 83 subjects died, though the exact relationship to the experiment remains undocumented. This study not only violated the Hippocratic Oath but it echoed
Nazi Nazism (), formally named National Socialism (NS; , ), is the far-right politics, far-right Totalitarianism, totalitarian socio-political ideology and practices associated with Adolf Hitler and the Nazi Party (NSDAP) in Germany. During H ...
crimes exposed around the same time at the
Nuremberg trials #REDIRECT Nuremberg trials {{redirect category shell, {{R from other capitalisation{{R from move ...
. In December of 1954, Cutler was in charge of experiments at
Sing Sing Sing Sing Correctional Facility is a maximum-security prison for men operated by the New York State Department of Corrections and Community Supervision in the village of Ossining (village), New York, Ossining, New York, United States. It is abou ...
Penitentiary in Ossining, New York to determine whether a
vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...
made from the killed syphilis
bacterium Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the ...
would protect prisoners against infection when he later exposed them to the bacterium. The physicians conducted experiments over the course of 15 months including 62 volunteer prisoners at the Sing Sing Penitentiary. Those infected were later treated with
penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...
. Cutler, who was acting chief, briefed the program to the Federal Public Health Service during the yearl
American Academy of Dermatology and Syphilology.
Cutler became assistant surgeon general in 1958. In the 1960s until November 1972, Cutler was involved in the ongoing
Tuskegee syphilis experiment The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Cent ...
, during which several hundred
African-American African Americans, also known as Black Americans and formerly also called Afro-Americans, are an American racial and ethnic group that consists of Americans who have total or partial ancestry from any of the Black racial groups of Africa. ...
men who had contracted syphilis were observed, but left untreated. In “The Deadly Deception”, the 1993 '' Nova'' documentary about the Tuskegee experiments, Cutler states, “It was important that they were supposedly untreated, and it would be undesirable to go ahead and use large amounts of penicillin to treat the disease, because you’d interfere with the study.” In 1967 Cutler was appointed Professor of International Health at the
University of Pittsburgh The University of Pittsburgh (Pitt) is a Commonwealth System of Higher Education, state-related research university in Pittsburgh, Pennsylvania, United States. The university is composed of seventeen undergraduate and graduate schools and colle ...
, where he also served as chairman of the Department of Health Administration and acting dean of the Graduate School of Public Health in 1968–1969. He died on February 8, 2003, at Western Pennsylvania Hospital in
Pittsburgh Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of Un ...
. The university started a lecture series in his name after his death, but discontinued it in 2008 when his role in the Tuskegee experiment came to the attention of a new dean.Torsten Ove:
Presidential panel excoriates former Pitt dean
, ''Pittsburgh Post-Gazette'', 29 August 2011


See also

* Juan María Funes * La Follette–Bulwinkle Act * List of medical ethics cases * Susan Mokotoff Reverby


References

{{DEFAULTSORT:Cutler, John Charles 1915 births 2003 deaths University of Pittsburgh faculty United States Public Health Service personnel Physicians from Cleveland Case Western Reserve University alumni Human subject research in the United States Medical ethics