Jean Dausset
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Jean-Baptiste-Gabriel-Joachim Dausset (19 October 1916 – 6 June 2009) was a French immunologist born in
Toulouse Toulouse (, ; ; ) is a city in southern France, the Prefectures in France, prefecture of the Haute-Garonne department and of the Occitania (administrative region), Occitania region. The city is on the banks of the Garonne, River Garonne, from ...
, France. Dausset received the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
in 1980 along with Baruj Benacerraf and
George Davis Snell George Davis Snell NAS (December 19, 1903 – June 6, 1996) was an American mouse geneticist and basic transplant immunologist. Work George Snell shared the 1980 Nobel Prize in Physiology or Medicine with Baruj Benacerraf and Jean Dausse ...
for their discovery and characterisation of the
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
s making the
major histocompatibility complex The major histocompatibility complex (MHC) is a large Locus (genetics), locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for Cell (biology), cell surface proteins essential for the adaptive immune system. The ...
. Using the money from his Nobel Prize and a grant from the French Television, Dausset founded the Human Polymorphism Study Center ( CEPH) in 1984, which was later renamed the Foundation Jean Dausset-CEPH in his honour. He married Rose Mayoral in 1963, with whom he had two children, Henri and Irène. Jean Dausset died on June 6, 2009, in
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, Spain, at the age of 92.


Early life

Jean-Baptiste-Gabriel-Joachim Dausset was born on 19 October 1916, in
Toulouse Toulouse (, ; ; ) is a city in southern France, the Prefectures in France, prefecture of the Haute-Garonne department and of the Occitania (administrative region), Occitania region. The city is on the banks of the Garonne, River Garonne, from ...
, France. He was the youngest of four children of Henri Dausset and Elisabeth Dausset (born Renard). His father was from the
Pyrénées The Pyrenees are a mountain range straddling the border of France and Spain. They extend nearly from their union with the Cantabrian Mountains to Cap de Creus on the Mediterranean coast, reaching a maximum elevation of at the peak of Aneto. F ...
, and was a doctor by profession, and his mother was a housewife from
Lorraine Lorraine, also , ; ; Lorrain: ''Louréne''; Lorraine Franconian: ''Lottringe''; ; ; is a cultural and historical region in Eastern France, now located in the administrative region of Grand Est. Its name stems from the medieval kingdom of ...
. Following the end of
World War I World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to ...
the Dausset family moved to
Biarritz Biarritz ( , , , ; also spelled ; ) is a city on the Bay of Biscay, on the Atlantic coast in the Pyrénées-Atlantiques department in the French Basque Country in southwestern France. It is located from the border with Spain. It is a luxu ...
where Jean spent most of his childhood. His father was head doctor at the Bayonne Hospital, a position that would make a great impression on Jean. Dausset was home schooled by his mother, as well as by a tutor, who would periodically come to the house. At the age of 11, Dausset and his family moved to
Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...
. He began his formal schooling at the Lycée Michelet, at age 15. After earning his
Baccalauréat The ''baccalauréat'' (; ), often known in France colloquially as the ''bac'', is a French national academic qualification that students can obtain at the completion of their secondary education (at the end of the ''lycée'') by meeting certain ...
in mathematics, Dausset was convinced by his father to study medicine at the
University of Paris The University of Paris (), known Metonymy, metonymically as the Sorbonne (), was the leading university in Paris, France, from 1150 to 1970, except for 1793–1806 during the French Revolution. Emerging around 1150 as a corporation associated wit ...
. Both of Dausset's parents died just after he became an extern at the Paris Hospitals, at the age of 19. Dausset failed to pass an internship entrance exam at the Paris Hospitals, and was preparing for a second attempt when
World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...
broke out.


War

Dausset was enlisted in the French army, and sent off to
Northern Italy Northern Italy (, , ) is a geographical and cultural region in the northern part of Italy. The Italian National Institute of Statistics defines the region as encompassing the four Northwest Italy, northwestern Regions of Italy, regions of Piedmo ...
for a year. Upon his return to Paris in 1940, Dausset studied ardently and passed his medical
intern An internship is a period of work experience offered by an organization for a limited period of time. Once confined to medical graduates, internship is used to practice for a wide range of placements in businesses, non-profit organizations and g ...
ship exam. Soon after passing his exams, Dausset joined the
Free French Forces __NOTOC__ The French Liberation Army ( ; AFL) was the reunified French Army that arose from the merging of the Armée d'Afrique with the prior Free French Forces (; FFL) during World War II. The military force of Free France, it participated ...
in
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as an ambulance worker. He was originally stationed in Morocco, but was later sent to the more active Tunisia. Dausset got his first taste of
hematology Hematology (American and British English spelling differences#ae and oe, spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to bloo ...
when he had to perform numerous
blood transfusion Blood transfusion is the process of transferring blood products into a person's Circulatory system, circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used ...
s on wounded soldiers. As the war was winding down in 1944, Dausset returned to Paris where he worked in the Regional Blood Transfusion Center at the Saint-Antoine Hospital.


Medical reform

After the war, Dausset worked as an intern at the Paris Hospitals, which were in a state of disrepair and badly needed structural reform. Dausset formed a group of radical doctors who pushed for change in the French medical system. Due to his activist role in this group, Dausset was appointed as the Advisor to the Cabinet of the National Ministry of Education. The physician Robert Debré worked with Dausset, and pushed the government into forming a committee for the reform of medical education. Hospitals were joined with universities for the first time in France, and doctors were required to instruct classes to medical students. With the newly introduced system of university research hospitals, research began within the hospitals themselves, as opposed to in the universities alone, and full-time work for doctors was established (''Debré reform'' of 11 and 30 December 1958).


Career

After World War II Dausset worked with Professor Marcel Bessis who had developed a new transfusion technique called exchange transfusion. He worked as an immunohematologist and was interested in anaemic patients who required blood transfusions, he found that these patients lacked both red and white blood cells. In 1948, Dausset went to work as an intern in the Children's Hospital in
Boston Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...
. He worked there in a hematology lab for about four years. He returned to France in 1952 and once again took up the position of an intern with Marcel Bessis. It was during this time that Dausset conducted his first official research. With Bessis, Dausset discovered the first antigen-presenting leucocyte, but it was only officially described in 1958. Between the years 1952 and 1957 he collaborated with many researchers such as Gilbert Malinvaud and Jacques and Monique Colombani. From 1952 to 1957, majority of Dausset's time went into developing techniques and developing further ways of confirming the presence of certain antibodies. He was made the head of research at Professor Georges Marchal’s immunohematology laboratory in the Broussais Hospital. During this time, Dausset performed blood transfusions between a voluntary donor and patients in order to further his research in the field of immune responses in the body. He was testing the ability of the antigen-presenting leucocytes in the recipient’s body, which came originally from the donor’s blood. In 1958, Dausset discovered an antibody called MAC which was a leuco-agglutinate; the abbreviation MAC actually stands for the initials of the names of the donors whose blood Dausset and his colleagues had used during the research. From 1960 to 1965 Dausset worked primarily on improving
organ transplantation Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be trans ...
techniques and the mechanisms involved in enhancing the body’s ability to accept the new tissue. To do this, Dausset again used the blood of voluntary donors and patients to see what differences lay in the blood of the two individuals and how to minimize these differences. 1965 was a crucial year for research. There was an intense competition amongst the researchers of the immunohematology field as everyone was on the brink of making a major discovery in the genetic and transplantation research. During this time, Dausset worked with Paul Ivany in
Prague Prague ( ; ) is the capital and List of cities and towns in the Czech Republic, largest city of the Czech Republic and the historical capital of Bohemia. Prague, located on the Vltava River, has a population of about 1.4 million, while its P ...
and they used leuco-agglutination and lymphocyte toxicity techniques to make some very significant discoveries. They discovered the Hu-1 antigen and the H-2 antigen. In 1963 Jean Dausset became the head of the immunology at the Hôpital Saint-Louis in 1963. This is when he discovered the HLA system, with Felix Rapaport; by performing skin transplant experiments on volunteers and showed that success depended on
histocompatibility Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses many uni ...
. Dausset was the assistant director of the Research Institute in Blood diseases until 1968, he then became the director of the " Institut National de la Santé et de la Recherche Médicale"(INSERM) transplantation immunogenetics research unit. Dausset founded France Transplant and France Greffe de Moelle, which brings matching donor organs to recipients and provides
bone marrow Bone marrow is a semi-solid biological tissue, tissue found within the Spongy bone, spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It i ...
for transplant respectively.


Research

Dausset began his research shortly after obtaining his medical degree in 1945, while working as an intern in the
hematology Hematology (American and British English spelling differences#ae and oe, spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to bloo ...
lab at the Children’s Hospital in Boston. His first paper was published in 1950, and dealt with the detection of incomplete antibodies using
trypsin Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the dig ...
ized
erythrocyte Red blood cells (RBCs), referred to as erythrocytes (, with -''cyte'' translated as 'cell' in modern usage) in academia and medical publishing, also known as red cells, erythroid cells, and rarely haematids, are the most common type of blood ce ...
s in a plasmatic medium, a technique that displayed improved sensitivity over other techniques used at the time. He went on to publish more works in the field of hematology, including developing a technique in 1952 for the removal of plasma from red blood cells to be used in transfusions to patients somehow intolerant of whole blood transfusions. In 1952 he returned to France and continued his research, particularly focusing on hemolytic anemia, and publishing several works dealing with various forms of blood cell agglutination. It was during this period of research, in 1954, when Dausset first observed an anti- leucocyte
agglutinating An agglutinative language is a type of language that primarily forms words by stringing together morphemes (word parts)—each typically representing a single grammatical meaning—without significant modification to their forms ( agglutinations) ...
substance, though it was not until 1958 that he identified an isoantibody specific to leucocytes, and published his findings. It was this finding and the extensive cascade of work that followed that would ultimately earn Dausset his
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
. General research in
antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ...
, agglutination, and
anemia Anemia (also spelt anaemia in British English) is a blood disorder in which the blood has a reduced ability to carry oxygen. This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin availabl ...
continued in the years following this 1958 paper. In 1962, Dausset published an examination of the correlation between leuco-agglutination and skin graft tolerance, his first observation of the
antigen In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...
s’ impact on
histocompatibility Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses many uni ...
. His next paper on the subject was published in 1964, when he observed a clear relationship between leucocyte antigen compatibility and antibody response to skin grafts. This finding sparked a flurry of research in the topic of histocompatibility, and by the end of 1965 Dausset had published over a dozen papers exploring leucocyte antigens and their relevance to histocompatibility. After identifying that a two-
allele An allele is a variant of the sequence of nucleotides at a particular location, or Locus (genetics), locus, on a DNA molecule. Alleles can differ at a single position through Single-nucleotide polymorphism, single nucleotide polymorphisms (SNP), ...
leucocyte antigen group had an influence on histocompatibility and observing the induction of hyper-sensitivity to skin grafts following injection of leucocyte fractions, Dausset developed a system for grouping leucocyte antigens on the basis of histocompatibility. Following this, he put forth the hypothesis that all known leucocyte antigens were part of a single complex, a complex which he named Hu-1. This complex would later become known as one of the
Major Histocompatibility Complex The major histocompatibility complex (MHC) is a large Locus (genetics), locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for Cell (biology), cell surface proteins essential for the adaptive immune system. The ...
es (MHC), specifically those termed Human Leucocyte Antigens (HLA). Dausset's further work in 1965 examining the effects of Hu-1 antigen injection on skin graft rejection further confirmed the conclusion that this Hu-1 complex was indeed a transplantation antigen, a conclusion which would in time have profound effects on the transplantation process. In the years to come, Dausset continued his research on the Hu-1 complex. Through 1966-1967 he published several more papers on the subject, including a paper summarizing the relevance of Hu-1 antigens to oncogenesis and transplantation, development of the use of a
platelet Platelets or thrombocytes () are a part of blood whose function (along with the coagulation#Coagulation factors, coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a thrombus, blood clot. Platelets have no ...
complementation fixation test to identify which antigens are present, and the discovery that Hu-1 is homologous to the mouse H-2 complex, which also functions in histocompatibility. Toward the end of 1967 he confirmed through familial studies that all discovered antigens were in fact part of a single system. Following 1967, Dausset participated in numerous other studies pertaining to the complex (which was renamed HLA in 1968), particularly those examining the genetic basis for the antigens’ transmission, along with publishing a number of other papers for which he claimed primary authorship. For his contribution to these studies as well as his ultimate role in the discovery of this crucial antigen, Jean Dausset received the
Nobel Prize in Physiology and Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single ...
in 1980. Following his reception of the Nobel Prize, Dausset's personal research slowed considerably. He contributed to multiple studies, particularly a number relating to genetics, but did not publish anything for which he claimed primary authorship for over a decade. He retired in 2003, at the age of 87.


Nobel Prize

In 1975, Dausset suspected that his name had been entered in the nominations for the Nobel Prize. However, nothing came of this until February 1980, when rumours were circulating in the scientific community about his possible candidacy. At this point, Dausset was planning on going to
Quebec Quebec is Canada's List of Canadian provinces and territories by area, largest province by area. Located in Central Canada, the province shares borders with the provinces of Ontario to the west, Newfoundland and Labrador to the northeast, ...
, Canada to do a conference series throughout the province. He was in a dilemma because if did win, he did not want to be away from his family and colleagues, and yet, were he to stay in France, people would suspect that he was sure of winning and he might set himself up for disappointment. So instead, he decided to stay in Paris, but to stay out of the public eye. He was unsurprisingly awarded the
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
1980, which he shared with Baruj Benacerraf and
George Davis Snell George Davis Snell NAS (December 19, 1903 – June 6, 1996) was an American mouse geneticist and basic transplant immunologist. Work George Snell shared the 1980 Nobel Prize in Physiology or Medicine with Baruj Benacerraf and Jean Dausse ...
.


Later life

In 1984 Dausset founded the Centre D’étude du Polymorphisme Humain (CEPH), aiming to detect the major genes in humans that are responsible for diseases outside the HLA system. Localization of these genes was a crucial step in cloning and identifying them, this was a breakthrough for medical genetics. The CEPH system contributed
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
from 61 large families to international centers that were responsible for mapping the human genome. Dausset and professor LL Cavalli-Sforza collaborated, and developed a DNA resource from world populations known as HGDP-CEPH diversity panel, to be used in human population genetics. CEPH is a non-profit organisation that was partly funded by the French government, it was not until 1993, that CEPH was renamed the Foundation Jean Dausset-CEPH. In 2003, at the age of 87, Dausset retired and became the president of CEPH. Dausset was a member of the French Academy of Sciences. He was also a professor at the college de France. Dausset was one of the influential foreign members of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
, US, and an honorary member of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...
. He was a member of the founding Council and Vice President of the
Human Genome Organization The Human Genome Organisation (HUGO) is a non-profit organization founded in 1988. HUGO represents an international coordinating scientific body in response to initiatives such as the Human Genome Project. HUGO has four active committees, includ ...
. Dausset received various prestigious prizes, such as the Landsteiner Award and prizes for the Koch and Wolf Foundations. He also served on the advisory boards of numerous research institutions.


References

* * Dausset, Jean, ''Clin d'oeil à la vie: La grande aventure HLA'', Paris, Odile Jacob, 1998. * * * *


External links


Jean Dausset
– Daily Telegraph obituary *

* ttp://www.cephb.fr/ CEPH– Official Site of the CEPH * {{DEFAULTSORT:Dausset, Jean 1916 births 2009 deaths Academic staff of the Collège de France French immunologists French hematologists French Nobel laureates Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Nobel laureates in Physiology or Medicine Wolf Prize in Medicine laureates Physicians from Toulouse University of Paris alumni Grand Cross of the Legion of Honour Inserm directors