Jay Shendure is an American scientist and human

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic process ...

at the

University of Washington The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the Uni ...

. He is a professor in the Department of Genome Sciences at the

University of Washington School of Medicine The University of Washington School of Medicine is the medical school of the University of Washington, a public research university in Seattle, Washington. According to ''U.S. News & World Report''s 2022 Best Graduate School rankings, University ...

and an Affiliate Investigator in the Human Biology Division at the

Fred Hutchinson Cancer Research Center The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington (state), Washington. History ...

. Shendure's research is focused on developing and applying new technologies in genomics. In 2005, his doctoral research with George M. Church resulted one of the first successful proof-of-concepts of next-generation

DNA sequencing DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, thymine, cytosine, and guanine. The ...

. Shendure's research group at the University of Washington pioneered

exome sequencing Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). It consists of two steps: the first step is to select only the subs ...

and its application to Mendelian disorders, a strategy that has been applied to identify hundreds of disease-causing genes. Other notable accomplishments of Shendure's laboratory include the first whole genome sequencing of a human fetus using samples obtained non-invasively from the parents, and the sequencing of the

HeLa HeLa () is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. HeLa cells are durable and prolific, allowing for extensive applications in scientific study. The line is ...

genome in agreement with

Henrietta Lacks Henrietta Lacks (born Loretta Pleasant; August 1, 1920 – October 4, 1951) Note: Some sources report her birthday as August 2, 1920, vs. August 1, 1920. was an African-American woman whose cancer cells are the source of the HeLa cell line, ...

' family. Shendure graduated summa cum laude from

Princeton University Princeton University is a private university, private Ivy League research university in Princeton, New Jersey, United States. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial ...

in 1996 and completed a Fulbright scholarship at Pune, India, in 1997. He then entered the

Medical Scientist Training Program The Medical Scientist Training Programs (MSTPs) are dual-degree training programs that streamline the education towards both clinical (typically MD) and research doctoral degrees. MSTPs are offered by some United States medical schools, who are aw ...

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

and received his Ph.D. in 2005 and his M.D. in 2007. He joined the faculty at the Department of Genome Sciences at the

in 2007 and was tenured as an associate professor four years later in 2011. Shendure is a 2006 recipient of the

TR35 The Innovators Under 35 is a peer-reviewed annual award and listicle published by ''MIT Technology Review'' magazine, naming the world's top 35 innovators under the age of 35. at '' Technology Review'' with lists of winners at technologyreview.com ...

Young Innovator Award from ''

MIT Technology Review ''MIT Technology Review'' is a bimonthly magazine wholly owned by the Massachusetts Institute of Technology. It was founded in 1899 as ''The Technology Review'', and was re-launched without "''The''" in its name on April 23, 1998, under then pu ...

'', the

Curt Stern Award The ASHG Scientific Achievement Award was established in 2001 and is presented annually by the American Society of Human Genetics (ASHG) for outstanding scientific achievements in human genetics that have occurred in the last 10 years. The award w ...

from the

American Society of Human Genetics The American Society of Human Genetics (ASHG), founded in 1948, is a professional membership organization for specialists in human genetics. As of 2009, the organization had approximately 8,000 members. The society's members include researchers, ...

in 2012, the FederaPrijs from the Federation of Dutch Medical Scientific Societies in 2013, a

National Institutes of Health Director's Pioneer Award National Institutes of Health Director's Pioneer Award is a research initiative first announced in 2004 designed to support individual scientists' biomedical research. The focus is specifically on "pioneering" research that is highly innovative ...

in 2013, and a Howard Hughes Medical Investigator Award. He is also the founding Scientific Director of the Brotman-Baty Institute established in 2017 through a gift from Jeffrey H. and Susan Brotman, and Daniel R. and Pamela L. Baty.

References

{{DEFAULTSORT:Shendure, Jay Year of birth missing (living people) Living people American geneticists Harvard Medical School alumni Princeton University alumni Richard-Lounsbery Award laureates