Interleukin 10 receptor, beta subunit is a subunit for the
interleukin-10 receptor. IL10RB is its human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
IL10RB has also been designated CDw210b (
cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...
w210b).
The protein encoded by this gene belongs to the
cytokine receptor
Cytokine receptors are receptors that bind to cytokines.
In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly be ...
family. It is an accessory chain essential for the active
interleukin 10 receptor complex. Coexpression of this and
IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, ''
IFNAR2
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the ''IFNAR2'' gene.
Function
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons a ...
'', ''
IFNAR1
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the ''IFNAR1'' gene.
Function
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interfer ...
'', and ''
IFNGR2'', form a
class II cytokine receptor gene cluster located in a small region on chromosome 21.
References
Further reading
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Clusters of differentiation
Type II cytokine receptors
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