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An interchromatin granule is a cluster in the nucleus of a mammal cell which is enriched in
pre-mRNA A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by Transcription (genetics), transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. The primary transcript ...
splicing factors. Interchromatin granules are located in the interchromatin regions of mammal cell nuclei. They usually appear as irregularly shaped structures that vary in size and number. They can be observed by immunofluorescence microscopy. Interchromatin granules are structures undergoing constant change, and their components exchange continuously with the nucleoplasm, active transcription sites and other nuclear locations. Research on dynamics of interchromatin granules has provided new insight into the functional organisation of the nucleus and gene expression. Interchromatin granule clusters vary in size anywhere between one and several micrometers in diameter. They are composed of 20–25 nm granules that are connected in a beaded chain fashion appearance by thin fibrils. Interchromatin granule clusters (IGCs) may represent small nuclear ribonucleoproteins (snRNPs) that have completed their maturation process and can be supplied to nearby areas containing perichromatin fibers where splicing is taking place. Other proteins, such as
RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ...
and certain
transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...
s, as well as poly-adenylated RNA may also be present. The maturation of snRNPs takes place in part in Cajal bodies, and IGCs may donate splicing factors to the snRNP.


See also

* are subnuclear structures that are enriched in pre-messenger RNA splicing factors


Notes


References

{{reflist Cell biology